Evidence map›Paper›PMID 40791480›Full record

ArticlebioRxiv : the preprint server for biology2025

A multi-omics analysis of human fibroblasts overexpressing an

Juan I Bravo, Eyael Tewelde, Christina D King, Joanna Bons, Samah Shah, Jacob Rose, Judith Campisi, Birgit Schilling, Bérénice A Benayoun

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Juan I BravoLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-9429-0488
Eyael TeweldeAlfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0009-0001-6073-3711
Christina D KingBuck Institute for Research on Aging, Novato, CA 94945, USA.
Joanna BonsBuck Institute for Research on Aging, Novato, CA 94945, USA.
Samah ShahBuck Institute for Research on Aging, Novato, CA 94945, USA.
Jacob RoseBuck Institute for Research on Aging, Novato, CA 94945, USA.
Judith CampisiBuck Institute for Research on Aging, Novato, CA 94945, USA.ORCID 0000-0001-6858-9462
Birgit SchillingBuck Institute for Research on Aging, Novato, CA 94945, USA.ORCID 0000-0001-9907-2749
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-7401-4777

Funding

USC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3M
USC-Buck Institute Nathan Shock Admin CoreP30AG068345 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI LITHGOW, GORDON J · 2020 to 2024
$5.0M
Understanding the regulation and impact of transposable elements in Vertebrate health and diseaseR35GM142395 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2021 to 2025
$2.2M
Orbitrap Fusion Lumos ETD with FAIMS ProS10OD028654 · OD · BUCK INSTITUTE FOR RESEARCH ON AGING · PI SCHILLING, BIRGIT · 2020 to 2020
$1.1M
NIA NIH HHS P30 AG068345NIA NIH HHS T32 AG052374NIGMS NIH HHS R35 GM142395NIH HHS S10 OD028654
6 · The paper itself

Abstract

During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human genome are

Indexed as

AgingAluCell CycleFibroblastsMitochondriaProteomicsProteostasisRetrotransposonsSecretomeTranscriptomics

Identifiers

PMID40791480
PMCPMC12338678

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.