ArticlebioRxiv : the preprint server for biology2025
When does accounting for gene-environment interactions improve complex trait prediction? A case study with
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gene-environment interactions (G×E) have been shown to explain a non-negligible proportion of variance for a plethora of complex traits in different species, including livestock, plants, and humans. While several studies have shown that including G×E can improve prediction accuracy in agricultural species, no increase in accuracy has been observed in human studies. In this work, we sought to investigate the reasons for the contradictory results between agricultural species and humans. Model organisms are useful for studying G×E, since environments can be controlled and genotypes can be replicated across environments. Thus, we used data from a previous study in
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