ArticlebioRxiv : the preprint server for biology2025
Principled measures and estimates of trait polygenicity.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection.PLoS genetics · 2026Article
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2 authors.
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Abstract
The 'polygenicity' of traits is often invoked and sometimes quantified in quantitative, statistical, and human genetics. What do we mean by the polygenicity of a trait? We propose a principled definition that encompasses a range of polygenicity measures. We show that these measures satisfy certain mathematical properties, we argue that these properties are sensible if not necessary, and we show that, conversely, measures that satisfy these properties also satisfy our definition. We consider four specific measures in greater detail, describe how they differ and show that three of them can be estimated from GWAS summary statistics using an existing method, Fourier Mixture Regression. We estimate these measures for 36 traits in humans. We find a dearth of traits with polygenicity values that fall within the large gap between Mendelian and highly polygenic traits. We discuss the evolutionary and cellular processes underlying trait polygenicity.
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