In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Ran SongDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0002-1564-527X Chigozie NgokaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0009-0002-6997-4404 Amika SinglaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0002-9454-9111 Daniel A KramerDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0002-7159-9562 Alka DiwakerDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0009-0002-2473-6074 Daniel J BoeschRoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA.ORCID 0009-0003-1656-9453 Qi LiuDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
James J MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0003-1178-1642 Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0002-3639-246X Hans-Christian ReineckerDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0001-8283-644X Ezra BursteinDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0003-4341-6367 Baoyu ChenDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0002-6366-159X Emre E TurerDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.ORCID 0000-0001-8782-3648 Funding
Regulation of Nutrient Homeostasis by COMMD proteinsR01DK107733 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DANIEL D BILLADEAU, Ezra Burstein · 2016 to 2026
$4.6MSignal Integration from Membranes to the Actin CytoskeletonR35GM128786 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Baoyu Chen · 2018 to 2026
$3.6MTVP23B and Golgi Mediated Control of Intestinal Secretory CellsR01DK133229 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Emre Erol Turer · 2024 to 2026
$1.8MThe Role of the Smcr8-Wdr41-C9orf72 (SWC) Complex in the Maintenance of Intestinal HomeostasisR01DK119360 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TURER, EMRE EROL · 2020 to 2023
$1.8MCholesterol Regulation Through Retriever-Dependent LDL Receptor RecyclingR01HL179813 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Ezra Burstein, Baoyu Chen · 2025 to 2026
$1.4MNHLBI NIH HHS R01 HL179813NIDDK NIH HHS R01 DK107733NIDDK NIH HHS R01 DK119360NIDDK NIH HHS R01 DK133229NIGMS NIH HHS R35 GM128786
6 · The paper itselfAbstract
Maintaining intestinal homeostasis relies on the intricate interplay among the mucosal epithelium, immune system, and host microbiome. A key question is how innate immune cells sense and process microbes in the gut lumen, eliciting appropriate protective responses without causing tissue injury. Clearance of invading microbes and initiation of downstream inflammatory responses are central to this process and require proper function of the endolysosomal system. Dysfunction of this system can predispose the host to chronic inflammatory disorders and acute infections. Here, through forward genetic screening of N-ethyl-N-nitrosourea (ENU)-mutagenized mice and CRISPR/Cas9 validation, we identify
Indexed as
Dextran sodium sulfate (DSS)inflammatory bowel disease (IBD)innate immunityLRMDALysosome related organelle (LRO)N-ethyl-N-nitrosourea (ENU)Rab32Retrievervesicle trafficking
Identifiers
PMID40791432
PMCPMC12338710
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390