Evidence map›Paper›PMID 40791414›Full record

ArticlebioRxiv : the preprint server for biology2025

Computational Prioritization of T Cell Epitopes to Overcome HLA Restriction and Antigenic Diversity in

Alexander J Laurenson, Brian G Pierce, Shannon Takala-Harrison, Matthew B Laurens

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander J LaurensonCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-2450-8015
Brian G PierceUniversity of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland, USA.ORCID 0000-0003-4821-0368
Shannon Takala-HarrisonCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-4674-8500
Matthew B LaurensCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3874-581X

Funding

VTEU SupplementUM1AI148689 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Karen L. Kotloff · 2020 to 2026
$52.7M
DON in Pediatric Cerebral Malaria: A Phase I / II Dose-Escalation Safety StudyU01AI155300 · NIAID · CHILDREN'S RESEARCH INSTITUTE · PI POSTELS, DOUGLAS · 2021 to 2025
$5.6M
CTSA Predoctoral T32 at Johns HopkinsT32TR004928 · NCATS · JOHNS HOPKINS UNIVERSITY · PI Meredith Ann Atkinson · 2024 to 2026
$1.6M
Gates Foundation INV-030857NCATS NIH HHS T32 TR004928NIAID NIH HHS U01 AI155300NIAID NIH HHS UM1 AI148689
6 · The paper itself

Abstract

Developing a highly effective malaria vaccine remains challenging due to

Indexed as

epitope predictionimmunoinformaticsmalariamulti-epitope vaccinePlasmodium falciparum

Identifiers

PMID40791414
PMCPMC12338633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.