Evidence map›Paper›PMID 40791403›Full record

ArticlebioRxiv : the preprint server for biology2025

A multiplex extracellular interactome screening method employing high-avidity nanoparticles.

Michael A Anaya, Maxine L Wang, Elisa Gonzalez, Annie W Lam, Pavee Vasnarungruengkul, Jost Vielmetter, Woj M Wojtowicz, Kai Zinn

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael A AnayaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-6944-3614
Maxine L WangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-5285-1857
Elisa GonzalezDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Annie W LamDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Pavee VasnarungruengkulDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Jost VielmetterDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-4314-7163
Woj M WojtowiczDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Kai ZinnDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-6705-5605

Funding

A Global Map of Interactions Among Human Cell Surface Proteins and Secreted LigandsR01GM150125 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GARCIA, KENAN CHRISTOPHER, THOMSON, MATTHEW W. · 2022 to 2025
$11.3M
NIGMS NIH HHS R01 GM150125
6 · The paper itself

Abstract

Metazoan cells signal to each other via direct contact between cell surface proteins (CSPs) and by interactions of CSP receptors with secreted ligands. CSP extracellular domain (ECD) interactions control organ development and physiology and are perturbed in disease states. However, because they cannot be accurately assessed using standard high-throughput screening techniques, they are underrepresented in protein interaction databases. Many ECD interactions are of low affinity, and their detection

Identifiers

PMID40791403
PMCPMC12338595

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.