Evidence map›Paper›PMID 40791384›Full record

ArticlebioRxiv : the preprint server for biology2025

Airway epithelial SARS-CoV-2 infectious and repair responses: relationships to age, sex, and post-COVID pulmonary syndromes.

Hong Dang, Caitlin E Edwards, Takafumi Kato, Boris Reidel, Rita M Meganck, Charles R Esther, Camille Ehre, M Leslie Fulcher, Alexis B Bailey, Michelle R Cooley and 17 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Hong DangMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-7305-4208
Caitlin E EdwardsDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-4228-2192
Takafumi KatoMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-2248-3376
Boris ReidelMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Rita M MeganckDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-2799-3754
Charles R EstherMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Camille EhreMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-0046-0096
M Leslie FulcherMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Alexis B BaileyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Michelle R CooleyThe University of Chicago Medical Center.ORCID 0000-0001-9277-828X
Yu MikamiMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-3262-2958
Takanori AsakuraMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-3122-6937
Padraig E HawkinsMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Minako FurushoMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Jeffrey L MyersDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI.
Kristine KonopkaDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0002-4582-0120
Firoozeh V GerayeliCentre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
Hye Yun ParkDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, South Korea.
Don D SinCentre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
Alessandra Livraghi-ButricoMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-8751-3631
Kenichi OkudaMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Raymond J PicklesMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-8875-148X
Sabra KleinBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-0730-5224
Scott H RandellMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Wanda K O'NealMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-2412-5943
Ralph S BaricDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-6827-8701
Richard C BoucherMarsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5M
Stanford/UNC Biomimetic U19 Research CenterU19AI116484 · NIAID · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2015 to 2025
$13.5M
Receptor recognition mechanisms of coronavirusesR01AI089728 · NIAID · UNIVERSITY OF MINNESOTA · PI Fang Li, Timothy Patrick Sheahan · 2010 to 2026
$4.7M
Mucociliary innate defense mechanism in the human distal airwayR01HL163602 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kenichi Okuda · 2023 to 2026
$2.4M
NHLBI NIH HHS R01 HL163602NIAID NIH HHS R01 AI089728NIAID NIH HHS U19 AI116484NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

The long-term pulmonary sequelae of SARS-CoV-2 respiratory infections reflect infection severity, innate and adaptive immunity, and respiratory epithelial repair. This study investigated the acute and reparative responses as a function of age and sex in primary human bronchial epithelial (HBE) cultures utilizing a 14-day SARS-CoV-2 infection protocol. SARS-CoV-2 infection peaked at 3 days post-infection (dpi) with an ~ 2 log titer suppression at 14 dpi. SARS-CoV-2 infection induced interferon, interferon-induced gene, and cell damage responses. No age- or sex-dependent effects on SARS-CoV-2 infection were detected. Airway epithelia repaired to an abnormal mucus metaplastic/inflammatory state that reflected potentially beneficial and adverse consequences at 14 dpi. Repair processes were infection severity-dependent, not sex-dependent, and were more robust in young donor cultures. Analyses of long-COVID subjects with persistent pulmonary fibrosis or persistent bronchitic airway diseases exhibited expression of HBE 14 dpi failed repair gene signatures, including ISG gene signatures. Human airway epithelial repair post-SARS-CoV-2 is prolonged and incomplete

Identifiers

PMID40791384
PMCPMC12338744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.