Evidence map›Paper›PMID 40791381›Full record

ArticlebioRxiv : the preprint server for biology2025

Cell-type-specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer auditory cortical neurons after noise trauma.

Yanjun Zhao, Stylianos Kouvaros, Nathan A Schneider, Rebecca F Krall, Stephanie Lam, Megan P Arnold, Ross S Williamson, Thanos Tzounopoulos

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yanjun ZhaoDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA.
Stylianos KouvarosDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA.
Nathan A SchneiderDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA.
Rebecca F KrallDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA.
Stephanie LamDepartment of Bioengineering, University of Pittsburgh, Pittsburgh PA.
Megan P ArnoldDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA.
Ross S WilliamsonDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA.
Thanos TzounopoulosDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA.

Funding

Extratelencephalic contributions to auditory categorizationR01DC020459 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ross Stewart Williamson · 2022 to 2026
$3.4M
Synaptic, Cellular and Circuit Mechanisms of Cortical Plasticity after Cochlear DamageR01DC019618 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TZOUNOPOULOS, THANOS · 2021 to 2025
$3.1M
Cortical neuromodulatory mechanisms underlying adaptation and plasticityR01DC020923 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thanos Tzounopoulos · 2023 to 2026
$2.3M
Functional Organization of Auditory Corticofugal CircuitsR21DC018327 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILLIAMSON, ROSS STEWART · 2019 to 2021
$603k
NIDCD NIH HHS R01 DC019618NIDCD NIH HHS R01 DC020459NIDCD NIH HHS R01 DC020923NIDCD NIH HHS R21 DC018327
6 · The paper itself

Abstract

Peripheral trauma, such as noise-induced hearing loss (NIHL), triggers compensatory plasticity in the auditory cortex (ACtx) to maintain auditory function. While cortical plasticity in superficial cortical layers has been relatively well studied, the plasticity mechanisms governing deep-layer excitatory projection neurons remain less understood. Here, we investigated the plasticity of layer (L)5 extratelencephalic (ETs) and L6 corticothalamic neurons (CTs) following NIHL. Using a combination of

Indexed as

auditory cortexexcitatory neuronsin vitro electrophysiologyin vivo imagingnoise-induced hearing lossplasticitythalamocortical circuits

Identifiers

PMID40791381
PMCPMC12338564

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.