Evidence map›Paper›PMID 40791350›Full record

ArticlebioRxiv : the preprint server for biology2025

Metabolic imprinting drives epithelial memory during mucosal fungal infection.

Jinendiran Sekar, Norma V Solis, Jian Miao, Nicolas Millet, Bryce Tom, Derek Quintanilla, Aize Pellon, David L Moyes, Joseph A Gogos, Harry B Rossiter and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jinendiran SekarDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Norma V SolisDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Jian MiaoDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Nicolas MilletDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Bryce TomDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Derek QuintanillaDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Aize PellonCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
David L MoyesCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Joseph A GogosDepartment of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Harry B RossiterThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Scott G FillerDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands.
Jennifer K YeeDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Marc SwidergallDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-5261-6267

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
Systems Epigenomics of Persistent Bloodstream InfectionU19AI172713 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Monica Cappelletti · 2023 to 2026
$11.6M
Mechanism Underlying the Transduction of Epimutations from the Soma to the Male GermlineP50HD098593 · NICHD · UNIVERSITY OF NEVADA RENO · PI ZHOU, TONG · 2019 to 2024
$7.2M
Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis PatientsR01DK122767 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RHEE, CONNIE MEEYOUNG · 2019 to 2023
$3.3M
Novel cardiopulmonary exercise testing variables to differentiate neuromuscular deconditioning from diseaseR01HL166850 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Harry B Rossiter · 2023 to 2026
$3.1M
COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics ApproachesR01HL153460 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2021 to 2024
$2.7M
Oral commensal fungi and structural immunityR01DE031382 · NIDCR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Marc Swidergall · 2022 to 2026
$2.5M
Determinants of 5 Year Progression of Muscle Dysfunction and Inactivity in COPDGene Participants Diversity SupplementR01HL151452 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ADAMI, ALESSANDRA, ROSSITER, HARRY B · 2020 to 2023
$1.6M
NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS R01 HL151452NHLBI NIH HHS R01 HL153460NHLBI NIH HHS R01 HL166850NIAID NIH HHS U19 AI172713NICHD NIH HHS P50 HD098593NIDCR NIH HHS R01 DE031382NIDCR NIH HHS R37 DE022550NIDDK NIH HHS R01 DK122767
6 · The paper itself

Abstract

Epithelial cells at barrier sites are emerging as active participants in innate immune memory, yet the underlying metabolic and epigenetic mechanisms remain unclear. Here, we uncover a previously unrecognized form of trained immunity in oral epithelial cells that enhances protection against fungal infection. Using a mouse model, we show that mucosal exposure to

Indexed as

Candida albicansfatty acid oxidationoral epitheliumproline catabolism

Identifiers

PMID40791350
PMCPMC12338579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.