Evidence map›Paper›PMID 40791348›Full record

ArticlebioRxiv : the preprint server for biology2025

Endothelial Trauma Depends on Surface Charge and Extracellular Calcium Levels.

Jade H Cleary, Kara J Wentzel, Abigail J Howard, Adrian M Sackheim, Sophia H Piffard, Rushi Sonawane, Mohamed S Ahmed, Lydia Sheeser, J Cory Benson, Grant Hennig and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jade H ClearyDepartments of Emergency Medicine, University of Vermont, Burlington VT.
Kara J WentzelDepartments of Emergency Medicine, University of Vermont, Burlington VT.
Abigail J HowardDepartments of Emergency Medicine, University of Vermont, Burlington VT.
Adrian M SackheimDepartments of Emergency Medicine, University of Vermont, Burlington VT.
Sophia H PiffardDepartments of Emergency Medicine, University of Vermont, Burlington VT.
Rushi SonawaneDepartments of Emergency Medicine, University of Vermont, Burlington VT.
Mohamed S AhmedDepartments of Emergency Medicine, University of Vermont, Burlington VT.
Lydia SheeserDepartments of Emergency Medicine, University of Vermont, Burlington VT.
J Cory BensonDepartment of Pharmacology and Chemical Biology and Vascular Medicine Institute, University of Pittsburgh, Pittsburg PA.
Grant HennigDepartments of Pharmacology, University of Vermont, Burlington VT.ORCID 0000-0001-7436-9458
Dev MajumdarDepartments of Surgery, University of Vermont, Burlington VT.ORCID 0000-0002-2541-3851
Mohamed TrebakDepartment of Pharmacology and Chemical Biology and Vascular Medicine Institute, University of Pittsburgh, Pittsburg PA.ORCID 0000-0001-6759-864X
Mark T NelsonDepartments of Pharmacology, University of Vermont, Burlington VT.ORCID 0000-0002-6608-8784
Kalev FreemanDepartments of Emergency Medicine, University of Vermont, Burlington VT.ORCID 0000-0003-4817-2955

Funding

Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kristen Pierce · 2018 to 2026
$24.9M
Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Diego Adrianzen Herrera · 2020 to 2026
$17.4M
Endothelial Dysfunction and Restoration in Trauma Induced CoagulopathyR01HL166944 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mitchell Cohen, Kalev Freeman · 2023 to 2026
$9.2M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4M
Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDR01NS119971 · NINDS · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2021 to 2025
$2.6M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Lesions and loss of smooth muscle cells in brain underlies small vessel diseaseRF1NS128963 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JOUTEL, ANNE, NELSON, MARK T · 2022 to 2023
$2.2M
R35 Undergraduate Research SupplementR35GM144099 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kalev Freeman · 2022 to 2026
$2.2M
Impact of Trauma and its Products on Vascular Endothelial FunctionR01GM123010 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FREEMAN, KALEV · 2017 to 2021
$1.5M
Lesions and Loss of Smooth Muscle Cells in Brain Underlies Small Vessel DiseaseR01NS128963 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MARK T NELSON · 2025 to 2026
$1.3M
Acquisition of a new Flow CytometerS10OD026843 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOYSON, JONATHAN E · 2019 to 2019
$204k
NHLBI NIH HHS R01 HL166944NHLBI NIH HHS R35 HL140027NHLBI NIH HHS R35 HL150778NIGMS NIH HHS P20 GM125498NIGMS NIH HHS P20 GM135007NIGMS NIH HHS R01 GM123010NIGMS NIH HHS R35 GM144099NIH HHS S10 OD026843NINDS NIH HHS R01 NS110656NINDS NIH HHS R01 NS119971NINDS NIH HHS R01 NS128963NINDS NIH HHS RF1 NS128963
6 · The paper itself

Abstract

We tested the hypothesis that the ubiquitous store-operated Ca

Identifiers

PMID40791348
PMCPMC12338662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.