Evidence map›Paper›PMID 40791335›Full record

ArticlebioRxiv : the preprint server for biology2025

Pupil dilation as a marker of attention/effort in aging and mild cognitive impairment.

Alina Zhunussova, Clare Loane, Elif Kurt, Grazia Daniela Femminella, Sabrina Lenzoni, Millie Duckett, Martina F Callaghan, Nikolaus Weiskopf, Raymond J Dolan, Robert Howard and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alina ZhunussovaDepartment of Psychology, University of Innsbruck, Universitätsstraße 5-7, 6020 Innsbruck, Austria.ORCID 0009-0008-0167-5364
Clare LoaneInstitute of Cognitive Neuroscience, University College London, Alexandra House, 17-19 Queen Square, London WC1N 3AZ, United Kingdom.
Elif KurtDepartment of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Topkapı, Gureba Hastanesi Cd No:69, 34093 Fatih/İstanbul, Türkiye.ORCID 0000-0003-1956-575X
Grazia Daniela FemminellaDepartment of Translational Medical Sciences, University of Naples Federico II, Via Sergio Pansini, 5, 80131 Napoli, Italy.
Sabrina LenzoniDepartment of Psychology, University of Innsbruck, Universitätsstraße 5-7, 6020 Innsbruck, Austria.
Millie DuckettInstitute of Cognitive Neuroscience, University College London, Alexandra House, 17-19 Queen Square, London WC1N 3AZ, United Kingdom.
Martina F CallaghanDepartment of Imaging Neuroscience, University College London, Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.
Nikolaus WeiskopfWellcome Centre for Human Neuroimaging, Queen Square Institute of Neurology, University College London, 12 Queen Square, London WC1N 3AR, United Kingdom.
Raymond J DolanWellcome Centre for Human Neuroimaging, Queen Square Institute of Neurology, University College London, 12 Queen Square, London WC1N 3AR, United Kingdom.
Robert HowardDivision of Psychiatry, University College London, Maple House, 149 Tottenham Ct Rd, London W1T 7NF, United Kingdom.
Emrah DüzelInstitute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, House 64, Leipziger Str. 44, 39120 Magdeburg, Germany.
Dorothea HämmererDepartment of Psychology, University of Innsbruck, Universitätsstraße 5-7, 6020 Innsbruck, Austria.

Funding

Representational dynamics for flexible learning in complex environmentsR01MH126971 · NIMH · BROWN UNIVERSITY · PI Matthew Nassar · 2022 to 2026
$3.0M
NIMH NIH HHS R01 MH126971Wellcome Trust
6 · The paper itself

Abstract

Pupil dilation (PD) can be easily measured and reflects responses to subjectively salient or cognitively demanding events. It therefore holds promise as a cognitive marker especially for individuals with mild cognitive impairment (MCI) or other neurodegenerative conditions with restricted abilities to respond in cognitive assessments. We assessed PD during two tasks, an oddball task for investigating attentional allocation and a Simon task which additionally allows for investigating cognitive effort in younger adults (YAs), older adults (OAs), and patients with MCI. PD is a useful marker for investigating attention and cognitive effort in MCI, as suggested by elevated PD to salient stimuli in particular of individuals with better attentional control in MCI patients, as well as YAs and OAs. Measurement of PD may serve as an easy-to-administer measure to assess changes in cognitive function in healthy aging and MCI.

Indexed as

attentional modulationcognitive effortlocus coeruleusmild cognitive impairmentpupil dilation

Identifiers

PMID40791335
PMCPMC12338740

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.