SynthesisFrontiers in aging neuroscience2025
A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cognitive impairment is closely linked to immune system dysfunction, with increasing research interest in the underlying mechanisms and potential therapeutic targets. Bibliometric analysis provides a comprehensive approach to understanding research trends, influential contributions, and emerging topics in this interdisciplinary field. Methods: This study conducted a bibliometric analysis of publications related to the immune system and cognitive impairment from 1985 to 2024, retrieved from the Web of Science Core Collection. CiteSpace (6.4. R1), VOSviewer (1.6.20), and R-bibliometrix (R 4.3.0) were employed to analyze publication trends, co-authorship networks, keyword clustering, and co-citation patterns. Key metrics, including the H-index, G-index, and M-index, were computed to assess academic influence. Results: A total of 3,737 publications were analyzed, revealing a significant increase in research output since 2021. The United States and China emerged as leading contributors, with a robust presence of collaborative networks. Keyword and co-citation analysis identified core research themes, including neuroinflammation, microglia activation, gut microbiota, TREM2-mediated immune responses, and inflammasomes. Emerging topics such as the gut-brain axis, metabolic syndromes, and immune regulation in neurodegenerative diseases have gained prominence in recent years. Highly cited papers highlighted the role of immune dysregulation in Alzheimer's disease, multiple sclerosis, and HIV-associated neurocognitive disorders. Conclusion: This bibliometric analysis provides a comprehensive overview of research trends in immune-related cognitive impairment. The findings indicate an increasing focus on neuroinflammatory mechanisms, immune cell interactions, and novel immunotherapeutic strategies. Future research is expected to further explore the gut-immune-brain axis and precision medicine approaches in managing cognitive disorders. These findings may facilitate early detection strategies and novel interventions targeting immune-cognitive interactions, such as gut-brain axis modulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.