ArticleFrontiers in nutrition2025
Joint association of frailty and depression with new-onset digestive disease among elderly Chinese population.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Depression and risk of incident heart diseases among older adults at CKM stages 0-3: evidence from the China Health and Retirement Longitudinal Study.Annals of medicine · 2026Article
- Longitudinal frailty trajectories and risk of incident chronic liver disease among middle-aged and older Chinese adults: the mediating role of depressive symptoms.Research square · 2026Article
- Impact of Heart Disease and Multimorbidity on Oral Frailty in Japanese Community-Dwelling Older Adults.Circulation reports · 2026Article
- Grip strength in the association between frailty and new-onset depression in older adults: a multinational longitudinal study.Frontiers in public health · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Digestive diseases impose a substantial global health burden, yet the joint impact of frailty and depression on their incidence remains underexplored. Methods: This cohort study analyzed 5,506 adults aged ≥ 65 years from the China Health and Retirement Longitudinal Study (2011-2018). Participants with baseline digestive diseases or missing data were excluded. Cox proportional hazards models assessed associations, while mediation analysis evaluated bidirectional roles of the frailty index (FI) and 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) in new-onset digestive diseases. Results: Over 7 years, 988 participants developed digestive diseases. Frailty (HR = 1.66, Conclusion: Frailty and depression synergistically elevate digestive disease risk in aging populations, with bidirectional mediation underscoring their interdependence. Integrated interventions targeting mental health and geriatric vulnerability may mitigate disease burden.
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