Evidence map›Paper›PMID 40791174›Full record

ReviewCurrent opinion in organ transplantation2025

Forging a path toward kidney transplant equity through multilevel interventions.

Dinushika Mohottige, Clarissa J Diamantidis, Tanjala S Purnell, Regina M Longley, L Ebony Boulware

Registry-linked trialAbstract readReview
In one paragraph

Review in Current opinion in organ transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05014256 (System Interventions to Achieve Early and Equitable Transplants), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05014256 nacompletednot on this map

System Interventions to Achieve Early and Equitable Transplants (STEPS) Study

TypeinterventionalSponsorWake Forest University Health SciencesRan2022 to 2025Enrolled1,168ConditionsChronic Kidney DiseasesArmsSTEPS Health System Outreach intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dinushika MohottigeInstitute for Health Equity Research, Department of Population Health.
Clarissa J DiamantidisWake Forest School of Medicine.
Tanjala S PurnellDepartments of Epidemiology, Health Policy and Management, and Health Behavior and Society, Johns Hopkins Bloomberg School of Public Health.
Regina M LongleyInstitute for Health Equity Research, Department of Population Health.
L Ebony BoulwareWake Forest School of Medicine.

Funding

Health system outreach to eliminate disparities in living kidney transplants (System Interventions to Achieve Early and Equitable Transplants (STEPS) StudyU01DK127918 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOULWARE, LEIGH E · 2020 to 2020
$5.6M
Structural Racism as a "Third hit" on kidney outcomes of Black individuals with APOL1 risk allelesK23DK139454 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Dinushika Mohottige · 2024 to 2026
$583k
NIDDK NIH HHS K23 DK139454NIDDK NIH HHS U01 DK127918
6 · The paper itself

Abstract

purpose of reviewPersistent disparities in access to kidney transplantation, particularly living donor transplant and preemptive transplant, have gained increasing national attention including efforts to describe their multifactorial root causes. Multilevel structural impediments occurring at the recipient, donor, clinician, and health system level contribute to these disparities. This review overviews these key barriers, as well as recent successful interventions designed to address longstanding disparities. RECENT

findingsSeveral systems-level interventions including the Systems Intervention to Achieve Early and Equitable Transplants (STEPS) study (NCT05014256) may offer effective solutions to address critical roadblocks that lead to living donor kidney transplantation (LDKT) disparities by leveraging health system capabilities, coupled with individually-tailored support. Novel approaches leveraging community-based organizations, tele-health programs that overcome physical and transport related barriers, transplant navigators, and other individuals trained to meet patients' specific needs as they navigate complex transplant journeys, also offer promise. In addition, programs that fast-track complex evaluation requirements through tailored coordination offer promise to reduce racial and ethnic disparities in transplant receipt. SUMMARY: The success and sustainability of future interventions designed to eliminate longstanding transplant disparities will require concerted investments in multilevel interventions and access-enhancing policies that address the cascade of barriers impacting patients, donors, clinicians, and health systems.

Indexed as

Delivery of Health Care, IntegratedHealthcare DisparitiesHealth EquityHealth Services AccessibilityKidney Failure, ChronicKidney TransplantationLiving DonorsHumansTreatment Outcomekidney transplant equitymultilevel interventionsnavigationplace and systems-based interventions

Identifiers

PMID40791174
PMCPMC12465264

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.