Evidence map›Paper›PMID 40791166›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning.

Jing Yang, Du Cai, Junwei Liu, Zhenfeng Zhuang, Yibin Zhao, Feng-Ao Wang, Chenghang Li, Chuling Hu, Baowen Gai, Yiping Chen and 4 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
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  8. Review
  9. CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jing YangNational Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, 361005, China.
Du CaiDepartment of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Junwei LiuGuangzhou National Laboratory, Guangzhou, 510655, China.
Zhenfeng ZhuangDepartment of Computer Science at the School of Informatics, Xiamen University, Xiamen, 361005, China.
Yibin ZhaoDepartment of Colorectal Surgery, Ningbo Medical Center Lihuili Hospital (Affiliated Lihuili Hospital of Ningbo University), Ningbo, 315000, China.
Feng-Ao WangGuangzhou National Laboratory, Guangzhou, 510655, China.
Chenghang LiArtificial Intelligence Thrust, The Hong Kong University of Science and Technology, Guangzhou, 510655, China.
Chuling HuDepartment of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Baowen GaiDepartment of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Yiping ChenSchool of Geospatial Engineering and Science, Sun Yat-sen University, Zhuhai, 510655, China.
Yixue LiGuangzhou National Laboratory, Guangzhou, 510655, China.
Liansheng WangNational Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, 361005, China.ORCID https://orcid.org/0000-0002-2096-454X
Feng GaoDepartment of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.ORCID https://orcid.org/0000-0002-0500-5527
Xiaojian WuDepartment of General Surgery (Department of Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.ORCID https://orcid.org/0000-0001-5610-2530

Funding

Autonomous Region Natural Science Fund Plan Special Training Project 2022D03041Guangdong Basic and Applied Basic Research Foundation 2023A1515110196Guangdong Basic and Applied Basic Research Foundation 2023B1515130008Guangdong Basic and Applied Basic Research Foundation 2024A1515012269Guangdong Key Research and Development Project 2023B1111040003Guangzhou Basic and Applied Basic Research Fund 2024A04J9983Guangzhou Key Research and Development Project 202206080008Ministry of Science and Technology of the People's Republic of China STI2030-MajorProjects2021ZD0201900National Key Clinical DisciplineNational Natural Science Foundation of China 62371409National Natural Science Foundation of China 8227242Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0501600Postdoctoral Fellowship Program of CPSF GZC20233214Program of Guangdong Provincial Clinical Research Center for Digestive Diseases 2020B1111170004Shenzhen Medical Research Special Project D2401005Tianshan Talents Leading Medical Talents in Guangdong Province" Cooperative Expert Studio KSYJ2022001
6 · The paper itself

Abstract

Accurate risk stratification is crucial for determining the optimal treatment plan for patients with colorectal cancer (CRC). However, existing deep learning models perform poorly in the preoperative diagnosis of CRC and exhibit limited generalizability, primarily due to insufficient annotated data. To address these issues, CRCFound, a self-supervised learning-based CT image foundation model for CRC is proposed. After pretraining on 5137 unlabeled CRC CT images, CRCFound can learn universal feature representations and provide efficient and reliable adaptability for various clinical applications. Comprehensive benchmark tests are conducted on six different diagnostic tasks and two prognosis tasks to validate the performance of the pretrained model. Experimental results demonstrate that CRCFound can easily transfer to most CRC tasks and exhibit outstanding performance and generalization ability. Overall, CRCFound can solve the problem of insufficient annotated data and perform well in a wide range of downstream tasks of CRC, making it a promising solution for accurate diagnosis and personalized treatment of CRC patients.

Indexed as

Colorectal NeoplasmsSupervised Machine LearningTomography, X-Ray ComputedDeep LearningHumanscolorectal cancerfoundation modelprognosis predictionself‐supervised learning

Identifiers

PMID40791166
PMCPMC12591106

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.