Observational studyKorean journal of ophthalmology : KJO2025
Treatment Trends of Diabetic Macular Edema in Korea (TRACK) Study: A Prospective Multicenter Study.
Observational study in Korean journal of ophthalmology : KJO, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Deep Learning Prediction of Retinal Thickness from Near-Infrared Fundus Photography: Toward Decentralized Quantitative Assessment of Diabetic Macular Edema.Journal of personalized medicine · 2026Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
purposeTo evaluate real-world functional and anatomical outcomes, treatment patterns, and ocular examination trends in diabetic macular edema (DME) in Korea.
methodsA prospective, multicenter, observational study was conducted at 17 hospitals (2017-2022) involving adults with DME. Patients were categorized into center-involving DME (CI-DME) and non-CI-DME groups based on optical coherence tomography findings. Serial changes in best-corrected visual acuity (BCVA), central subfoveal thickness (CST), and treatment and examination patterns were recorded at baseline and follow-up visits (6, 12, 18, and 24 months), and analyzed using linear mixed models and paired t-tests.
resultsA total of 209 participants (81 female patients, 38.8%; mean age, 60.2 ± 10.8 years) were enrolled. Over 24 months, 10 of 68 non-CI-DME patients (14.7%) developed CI-DME. CST significantly decreased in the CI-DME group (from 419 µm at baseline to 343 µm, p = 0.001), whereas BCVA remained unchanged in both groups. Throughout the 2-year period, the average number of anti-vascular endothelial growth factor (anti-VEGF) injections was 3.1 ± 3.6, while steroid injections averaged 0.7 ± 1.5. The CI-DME group received significantly more anti-VEGF injections compared to the non-CI-DME group (3.8 ± 3.9 vs. 2.0 ± 2.8, p = 0.004). Additionally, the CI-DME group had more frequent visits (15.8 vs. 11.3, p = 0.017) and optical coherence tomography examinations (9.7 vs. 7.4, p = 0.023). The number of anti-VEGF injections decreased in the CI-DME group over time, while the number of visits decreased in both groups.
conclusionsIn real-world clinical practice in Korea, the treatment and monitoring frequency for DME was lower than in major clinical trials, potentially contributing to suboptimal visual outcomes.
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