Evidence map›Paper›PMID 40791110›Full record

ArticlePediatric pulmonology2025

Correlation of High Resolution CT Findings With Lung Function in Adolescents With Perinatally Acquired HIV on Anti-Retroviral Therapy.

Du Plessis Anne-Marie, Githinji Leah, N M Nyathi, Griffith Richards Stephanie, M Gray Diane, S Andronikou, J Zar Heather

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Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Du Plessis Anne-MarieDepartment of Paediatrics and Child Health, Red Cross Children's Hospital and South Africa Medical Research Council Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-2727-7582
Githinji LeahDepartment of Paediatrics and Child Health, Red Cross Children's Hospital and South Africa Medical Research Council Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.
N M NyathiDivision of Epidemiology and Biostatistics, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.
Griffith Richards StephanieDepartment of Radiology, Stellenbosch University, Stellenbosch, South Africa.
M Gray DianeDepartment of Paediatrics and Child Health, Red Cross Children's Hospital and South Africa Medical Research Council Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.
S AndronikouDepartment of Paediatric Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
J Zar HeatherDepartment of Paediatrics and Child Health, Red Cross Children's Hospital and South Africa Medical Research Council Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.

Funding

The authors received no specific funding for this study.
6 · The paper itself

Abstract

rationaleChronic lung disease is common in adolescents with perinatally acquired HIV (PHIV). HRCT provides delineation of chronic changes. Our aim was to investigate the association of HRCT findings with lung function in PHIV.

methodsProspective evaluation of participants in the Cape Town Adolescent Antiretroviral Cohort (CTAAC); perinatally infected YLHIV established on cART. HRCT was performed in participants with abnormal lung function (forced expiratory volume in 1 s [FEV1] of < 80% predicted and/or lung diffusion capacity [DLCO] < 80% predicted) or for clinical symptoms. Spirometry (pre and post bronchodilator) and DLCO (diffusion capacity) was correlated with HRCT findings.

resultsThere were 100 participants, (median [IQR] age 13.8 (IQR = 12.8, 15.1) years) 46% males. Median age at HIV diagnosis of 3.7 years (IQR = 1.6, 6.9). Median cART duration was 9.9 years (IQR = 7.1;11.5). CD4 count was > 500 cells/mm

conclusionMosaic attenuation and bronchiectasis were the most common abnormality on HRCT. The extent of these changes strongly correlated with reduced FEV

Indexed as

Anti-Retroviral AgentsHIV InfectionsLungTomography, X-Ray ComputedAdolescentChildFemaleForced Expiratory VolumeHumansInfectious Disease Transmission, VerticalMaleProspective StudiesRespiratory Function TestsSpirometryAnti-Retroviral Agentshigh resolution computed tomographylung function testingyouth living with HIV

Identifiers

PMID40791110
PMCPMC12340574

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