Evidence map›Paper›PMID 40791013›Full record

Trial reportDevelopmental psychobiology2025

Effects of Prenatal DHA Dose on Infant Visual Attention.

John Colombo, D Jill Shaddy, Nicole Mathis, Danielle N Christifano, Alexandra R Brown, Byron J Gajewski, Susan E Carlson, Kathleen M Gustafson

Registry-linked trialAbstract readRandomized Controlled TrialClinical Trial, Phase III
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Developmental psychobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02709239 (Prenatal Docosahexaenoic Acid), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02709239 nacompletednot on this map

Prenatal Docosahexaenoic Acid (DHA) & Neurofunctional Development

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2016 to 2021Enrolled300ConditionsUse and Dose of Prenatal DHA SupplementationArmsDHA 200mg, DHA 800mg
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John ColomboDepartment of Psychology and Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0002-6802-0820
D Jill ShaddyDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas, USA.
Nicole MathisDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas, USA.
Danielle N ChristifanoDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas, USA.
Alexandra R BrownDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Byron J GajewskiDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Susan E CarlsonDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas, USA.
Kathleen M GustafsonDepartment of Neurology and Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.

Funding

DHA Supplementation and Pregnancy OutcomeR01HD047315 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CARLSON, SUSAN E, COLOMBO, JOHN A. · 2006 to 2016
$4.9M
Prenatal DHA & Neurofunctional DevelopmentR01HD086001 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUSTAFSON, KATHLEEN M · 2016 to 2020
$3.1M
Psychometrics and Predictive Validity of Infant LearningR01HD109221 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI JOHN A. COLOMBO, Kimberly S Cuevas · 2023 to 2026
$2.6M
NICHD NIH HHS R01 HD047315NICHD NIH HHS R01 HD086001NICHD NIH HHS R01 HD109221NIH HHS HD086001NIH HHS HD103738
6 · The paper itself

Abstract

Prenatal supplementation with docosahexaenoic acid (DHA) has been reported to improve cognitive outcomes in infancy and early childhood in some studies. Existent studies have examined the effects of some dose of DHA against a true placebo; this report is the first to describe the effects of different doses of prenatal DHA on infant visual attention at 4 and 6 months of age. In a follow-up to a Phase III registered clinical trial (NCT02709239) designed to evaluate the effects of two prenatal doses of DHA supplementation (200 or 800 mg daily) on maternal physiology and fetal neurodevelopment, we assessed 215 infants delivered to these mothers at 4 and 6 months on a visual habituation task augmented with heart rate (HR) to assess visual stimulus processing, and a gap-overlap task to assess engagement and disengagement of attention. Infants of mothers supplemented with 800 mg/day of DHA had shorter look durations (indicative of more rapid visual learning) during habituation at both ages and a somewhat more mature pattern of HR-defined phases of attention. However, DHA dose did not affect infant HR, nor did it affect infant performance in the gap-overlap attention task. Results are consistent with positive effects of prenatal DHA supplementation on later outcomes, with higher benefit seen for a higher dose.

Indexed as

AttentionChild DevelopmentDietary SupplementsDocosahexaenoic AcidsPrenatal Exposure Delayed EffectsVisual PerceptionAdultFemaleFollow-Up StudiesHabituation, PsychophysiologicHumansInfantMalePregnancyDocosahexaenoic Acidsattentiondocosahexaenoic acidhabituationheart rateinfantlook durationocular reaction timeprenatal supplementation

Identifiers

PMID40791013
PMCPMC13182510

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.