Evidence map›Paper›PMID 40790950›Full record

ArticleJournal of traumatic stress2025

Prevalence of posttraumatic stress disorder and major depression in Ohio, Pennsylvania, and West Virginia 9 months after the East Palestine train derailment.

Cameron P Pugach, Aaron Reuben, Angela D Moreland, Alex O Rothbaum, John Boyle, Michael G Schmidt, James Dayton, Rachel Kinder, Sandro Galea, Salma Abdalla and 2 more

Abstract read
In one paragraph

Article in Journal of traumatic stress, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cameron P PugachDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Aaron ReubenDepartment of Psychology, University of Virginia, Charlottesville, Virginia, USA.
Angela D MorelandDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Alex O RothbaumDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA.
John BoyleICF International, Reston, Virginia, USA.
Michael G SchmidtDeparmtent of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
James DaytonICF International, Reston, Virginia, USA.
Rachel KinderICF International, Reston, Virginia, USA.
Sandro GaleaSchool of Public Health, Boston University, Boston, Massachusetts, USA.
Salma AbdallaSchool of Public Health, Boston University, Boston, Massachusetts, USA.
Mohammed Abba-AjiSchool of Public Health, Boston University, Boston, Massachusetts, USA.
Dean G KilpatrickDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.

Funding

Traumatic Stress Across the Lifespan: A Biopsychosocial Training ProgramT32MH018869 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CARLA KMETT DANIELSON, DEAN Gaines KILPATRICK · 1988 to 2026
$7.2M
Investigating neighborhood-environment contributions to midlife risk for dementiaF32ES034238 · NIEHS · DUKE UNIVERSITY · PI REUBEN, AARON · 2022 to 2024
$181k
NIEHS NIH HHS F32 ES034238NIEHS NIH HHS F32ES34238NIMH NIH HHS T32 MH018869NIMH NIH HHS T32MHO18869
6 · The paper itself

Abstract

On February 3, 2023, a Norfolk Southern train derailed in East Palestine, Ohio, releasing toxic compounds into the surrounding air, water, and soil. Technological chemical disasters represent potentially traumatic events capable of influencing mental disorders, such as posttraumatic stress disorder (PTSD) and major depression (MD). This study reports the first comprehensive investigation of the prevalence and correlates of mental disorders among potentially exposed residents of Ohio, Pennsylvania, and West Virginia 9 months postderailment. In this cross-sectional study, a nonprobability sample of 1,000 adults living within 65 miles of the derailment site completed a self-administered clinical survey interview assessing PTSD and MD, physical health symptoms, negative derailment-related beliefs and experiences, and preexisting psychiatric risk factors. Analyses were demographically weighted to yield estimates representative of the 65 mile-radius population. Most respondents were concerned about potential toxic exposure (73.9%) and associated health problems (92.1%), and half did not fully trust the information public health officials provided about the event (52.1%); half (49.7%) also reported at least one new or worsening physical health symptom since the derailment. Presumptive PTSD (15.4%) and MD (13.3%) were prevalent 9 months postderailment. Closer proximity to the derailment site was associated with greater endorsement of health concerns and symptoms, ds = 0.21-0.22, but not with greater mental disorder, OR = 1.02. Chemical disasters could have psychological consequences even without documented exposures, potentially due to uncertainty regarding exposure and associated health effects. The East Palestine community may benefit from increased attention to mental health services as a component of disaster response.

Indexed as

DisastersMajor Depressive DisorderRailroadsStress Disorders, Post-TraumaticAdolescentAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedOhioPennsylvaniaPrevalenceRisk Factors

Identifiers

PMID40790950
PMCPMC12711446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.