SynthesisArchives of public health = Archives belges de sante publique2025
Genetically proxied gut microbiota and cancer risk: a scoping review of Mendelian randomization studies.
Synthesis in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Microbiome-guided cancer immunotherapy: immune mechanisms, resistance pathways, and translational opportunities for precision oncology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- HPV52 predominates in cervical infections and precancerous lesions in Chongqing, China: a 6-year study linking genotypes to vaginal microecology.Frontiers in public health · 2026Article
- Genetically Predicted Gut Microbiota in Correlation with the Risk of Head and Neck Cancer.Cancer informatics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundCancer is a critical global health issue, and gut microbiota is considered a potential factor in the development of cancers. This review synthesizes evidence from Mendelian Randomization (MR) studies to explore the potential causal links between gut microbiota and cancer risk, thereby addressing the limitations inherent in observational studies.
methodsWe adopted a systematic literature review approach to search the PubMed, Embase, and Web of Science databases up to December 2023 for all MR studies examining the relationship between gut microbial diversity, strain-specific abundance, and cancer risk. Data extraction encompassed study design, study population, definition of microbial exposure, details of genetic instrument variables, sample size, effect estimates, and statistical significance. Given the diversity of genetic tools across different studies, the results of each study were presented in the form of a forest plot, and quality was assessed according to STROBE-MR criteria.
resultsWe reviewed 12 MR studies involving the relationships between 91 gut microbiota species and 14 types of cancer. The studies found that 64 of these gut microbiota species have potential protective effects against cancers, while 52 show tendencies to promote cancer development. Additionally, the relationship between 17 gut microbiota species and cancer remains unclear. Notably, the same gut microbiota species may have distinctly different impacts on different types of cancer.
conclusionDiverse gut microbiota have varied impacts on different cancer types. This microbial influence on cancer is not static; it changes dynamically. These changes are linked to variations in inflammation, metabolite adjustments, and differences in gut barrier function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.