Evidence map›Paper›PMID 40790599›Full record

ArticleJournal of nanobiotechnology2025

Tumor-microenvironment triggered Mn-Gd based nanosystem for breast carcinoma suppression via synergistic radiotherapy and glutathione-depleting along with glucose oxidase combination enhanced Ros storm.

Yonghui Su, Dongqun Guo, Yinghao Liang, Tuerdimaimaiti Meiheriban, Siyu Chen, Qian Tang, Xiqian Chen, Yan Huang, Jianqiao Zhong, Zongjunlin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yonghui Su *Department of Breast Surgery, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, 361003, P. R. China.
Dongqun Guo *Department of Urology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, P. R. China.
Yinghao LiangDepartment of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, 646099, P. R. China.
Tuerdimaimaiti MeiheribanDepartment of Breast Surgery, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, 361003, P. R. China.
Siyu ChenDepartment of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, 646099, P. R. China.
Qian TangDepartment of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, 646099, P. R. China.
Xiqian ChenDepartment of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, 646099, P. R. China.
Yan HuangSuining First People's Hospital, Suining, 629000, P. R. China. 45977773@qq.com.
Jianqiao ZhongDepartment of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, 646099, P. R. China. zjq7632@163.com.
Zongjunlin LiuDepartment of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, 646099, P. R. China. lzjl199388@foxmail.com.

Funding

Luzhou Municipal People's Government-Southwest Medical University Science and Technology Section Strategic Cooperation Project 2023ZD009National Science Foundation for the Young Scientists of China 82303078School-level research projects of Southwest Medical University 2023LZXNYDJ053
6 · The paper itself

Abstract

backgroundCancer treatment commonly involves radiation as a primary therapy, affecting nearly two-thirds of patients. The use of combination therapies is gaining traction, with the aim of achieving synergistic effects through the pharmacological interactions of multiple treatments. METHODS AND

resultsIn this study, we present a Mn-Gd-based bimetallic nanoplatform resembling a virus, designed with a rough surface for anchoring glucose oxidase enzymes (GOx) and coating with extracellular vehicles (EVs) on the outer layer (VMn-Gd@GOx-EVs). This platform enables a synergistic approach by combining radiation therapy (RT) with oxidative therapy. The nanoplatform offers four key benefits: targeted delivery to tumors through EVs, Mn and Gd ion release triggered by the tumor microenvironment, GOx-induced generation of H

conclusionRemarkably, the VMn-Gd@GOx-EVs platform effectively induces cell death in breast carcinoma models both in vitro and in vivo by harnessing the combined effects of RT and reactive oxygen species (ROS) generated by Mn ion catalysis under X-ray irradiation. Moreover, with its magnetic resonance imaging capabilities, this multi-functional diagnostic and therapeutic platform shows significant potential for clinical tumor treatment.

Indexed as

Breast NeoplasmsGadoliniumGlucose OxidaseGlutathioneManganeseReactive Oxygen SpeciesTumor MicroenvironmentAnimalsCell Line, TumorFemaleHumansHydrogen PeroxideMiceMice, Inbred BALB CMice, NudeGadoliniumGlucose OxidaseGlutathioneHydrogen PeroxideManganeseReactive Oxygen SpeciesFenton-like reactionH2O2 generation and GSH depletionSynergistic therapyTumor microenvironment triggeredTumor targeting

Identifiers

PMID40790599
PMCPMC12337444

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.