ArticleJournal of occupational medicine and toxicology (London, England)2025
Associations between pesticide exposure and hepatobiliary disease among agricultural workers in the Northeastern region of Thailand: a cross-sectional study.
Article in Journal of occupational medicine and toxicology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Evaluation of Liver Biomarker Levels in Farmers Occupationally Exposed to Pesticides: A Cross-Sectional Study.Diseases (Basel, Switzerland) · 2026Article
- Pesticides Drive Liver Diseases Through Non-Apoptotic Regulated Cell Death Pathways.Diseases (Basel, Switzerland) · 2026Review
- Behavioral Medicine in Cholangiocarcinoma: Bridging the Gap Between Biology and Behavior.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundOccupational exposure to pesticides has been linked to hepatobiliary diseases, particularly liver cancer and cholangiocarcinoma (CCA). In Thailand, pesticides are crucial for agriculture, enhancing crop protection and yields. This study aimed to determine the association between pesticide exposure and the prevalence of hepatobiliary diseases among agricultural workers in Northeastern Thailand.
methodsThe abdominal ultrasonographic findings of the CCA risk population were retrieved from the Isan cohort. Biological monitoring data on pesticide exposure were collected via serum cholinesterase testing from 8 provinces in Northeast Thailand, including Khon Kaen, Roi Et, Udon Thani, Nong Bua Lamphu, Kalasin, Buriram, Nakhon Phanom, and Sakon Nakhon provinces during 2016-2024. Data was analyzed using descriptive and inferential statistics with the STATA version 11.0 program.
resultsOf the 917 agricultural workers, the average age was 54.88 years (SD = 8.53), 552 were female (60.20%), and 365 were male (39.80%). The highest prevalence of hepatobiliary disease (46.03%) and abnormal serum cholinesterase levels (89.42%) among agricultural workers was observed in Sakon Nakhon province. The prevalence of abnormal serum cholinesterase in males (84.11%) was higher than in females (65.76%) (p < 0.001). Multiple logistic regression analyses showed a significantly positive association between abnormal serum cholinesterase levels and hepatobiliary diseases among agricultural workers (OR
conclusionsOur study highlights the association between pesticide exposure, indicated by abnormal serum cholinesterase levels, and an increased risk of hepatobiliary diseases. This finding underscores the importance of targeted interventions and public health policies that focus on educating agricultural workers on safe pesticide handling, promoting awareness campaigns, and implementing surveillance efforts to reduce exposure and mitigate the burden of hepatobiliary diseases, particularly in high-risk populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.