Trial reportBMC nephrology2025
The effect of oral melatonin on the quality of life, sleep and blood pressure of hemodialysis patients: a randomized clinical trial.
Trial report in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.Nutrients · 2025Pooled it
- Melatonin beyond chronobiology: integrating pharmacokinetics, dose-exposure forecasting, and clinical evidence.Molecular biology reports · 2026Review
- Circadian Influences on Chronic Kidney Disease Progression: Molecular Signaling Pathways of Melatonin and Their Therapeutic Potential.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Colon-targeted oral delivery of melatonin for regulating macrophage activity and intestinal barrier in ulcerative colitis.Theranostics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsidering the effect of melatonin on the quality of life and sleep in various diseases such as cancer, in the present study, the effect of melatonin was investigated on the quality of life, sleep, and blood pressure of hemodialysis patient.
methodsThis study was conducted as a double-blind clinical trial. The patients were randomly divided into two groups of 41 people receiving 3 mg of oral melatonin or placebo at night for six weeks. After taking written informed consent, all patients completed demographic, Pittsburgh Sleep Quality Index (PSQI), and Kidney Disease Quality of Life Questionnaire-Short Form (KDQOL-SF) questionnaires. The nurse of dialysis ward measured and recorded systolic and diastolic blood pressure in all patients during dialysis. At the end of the study, the questionnaires were completed again by the patients, and their blood pressure was measured and re-recorded. The data was statistically analyzed using SPSS software 24.
resultsMean age of patients in melatonin and placebo group was 48.97 ± 9.77 and 50.07 ± 12.65, respectively (p = 0.661). There was no statistically difference between two groups regarding gender distribution (p = 0.64) and Body mass index (p = 0.15), duration of hemodialysis (p = 0.54), systolic blood pressure (p = 0.7), diastolic blood pressure (p = 0.13), PSQI score (p = 0.73) and KDQOL-SF score in all domains (p > 0.05) before intervention. After intervention, there was no significant difference between two groups regarding systolic blood pressure (p = 0.83) and diastolic blood pressure (p = 0.21, but PSQI score (p = 0.0001) was significantly different between two groups. KDQOL-SF score in kidney disease domains was significantly different between two groups only in sleep domain (p = 0.003).
conclusionsThe present study showed that melatonin improves sleep quality but only sleep domain, physical function and energy domains of quality of life improved. There was no significant change in the blood pressure of the patients. It is recommended to conduct more studies with longer duration melatonin use for assessing its effect on quality of life and check 24- hour ambulatory blood pressure for precise assessment of melatonin effect on blood pressure.
trial registrationIRCT20230205057333N1, Date of registration: 2023/03/15, Available at http://www.irct.behdasht.gov.ir .
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