Evidence map›Paper›PMID 40790466›Full record

ArticleBMC cardiovascular disorders2025

The association of gene polymorphisms in SREBP and its interaction with nutritional status on blood pressure phenotypes among children: a cross-sectional study.

Yuan Zeng, Zehui Fan, Yulian Zhu, Hongju Tian, Mingxia Chen, Yue Gong, Bin Mao, Wanyun Xiang, Xiuqin Hong, Yide Yang

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yuan Zeng *Changsha Municipal Center for Disease Control and Prevention, Changsha, China.
Zehui Fan *Key Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Yulian Zhu *Department of Obstetrics, Hunan Prevention and Treatment Institute for Occupational Diseases, Affiliated Prevention and Treatment Institute for Occupational Diseases of University of South China, Changsha, China.
Hongju TianDepartment of Obstetrics, Hunan Prevention and Treatment Institute for Occupational Diseases, Affiliated Prevention and Treatment Institute for Occupational Diseases of University of South China, Changsha, China.
Mingxia ChenKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Yue GongKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Bin MaoKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Wanyun XiangKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Xiuqin HongKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Yide YangKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China. yangyide2007@126.com.

Funding

Hunan Province key research and development project 2023SK2059Hunan Provincial Natural Science Foundation of China 2019JJ50376Key Project of Developmental Biology and Breeding from Hunan Province 2022XKQ0205National College Student Innovation and Entrepreneurship Training Program S202410542075National Natural Science Foundation of China 81903336Scientific Research Fund of Hunan Provincial Education Department 22B0038Scientific Research Project of Hunan Provincial Health Commission 202112031516
6 · The paper itself

Abstract

introductionPrevious studies have confirmed that the SREBP polymorphisms are associated with dyslipidemia. However, no researchers investigated the association between SREBP polymorphisms and blood pressure phenotypes in children.

methodsA convenient cluster sampling method was adopted to conduct field survey in three middle schools. A total of 872 children were included in this cross-sectional study final analysis. Matrix-supported laser release/ionization time-of-flight mass spectrometry was used for genotyping of SREBP polymorphism. The association between SREBP polymorphisms and blood pressure phenotypes was analyzed by multivariable linear regression and Logistic regression analysis. A Bonferroni-corrected threshold of P < 0.025 (SREBP1) or P < 0.0125 (SREBP2) was considered significant.

resultsAfter adjusting for age, sex, age squared and BMI, individuals with GA/AA genotype of SREBP1/rs11868035 had higher systolic blood pressure (SBP) (β = 7.34, P = 0.004) than GG genotype, and SREBP1/rs2297508 C allele carriers were positively associated with SBP (β = 7.19, P = 0.008). A significant interaction between SREBP2/rs2228314 and gender on the risk of High Blood Pressure (HBP) (P

conclusionsSREBP polymorphisms were significantly associated with blood pressure in children. It provides possible clues for personalized prevention and intervention of HBP in children from the perspective of genetic susceptibility.

Indexed as

Blood PressureHypertensionNutritional StatusPediatric ObesityPolymorphism, Single NucleotideSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2AdolescentAge FactorsChildChinaCross-Sectional StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansSREBF1 protein, humanSREBF2 protein, humanSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2ChildrenHigh blood pressureNutritional statusPolymorphismsSREBP gene

Identifiers

PMID40790466
PMCPMC12337365

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