Evidence map›Paper›PMID 40790463›Full record

ArticleBMC geriatrics2025

Associations between malnutrition and physical performance, sarcopenia, and frailty in older adults.

Hélio José Coelho-Júnior, Alejandro Álvarez-Bustos, Andrea Russo, Leocadio Rodriguez-Mañas, Francesco Landi, Emanuele Marzetti

Abstract read
In one paragraph

Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hélio José Coelho-JúniorFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. coelhojunior@hotmail.com.br.
Alejandro Álvarez-BustosBiomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain.
Andrea RussoFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Leocadio Rodriguez-MañasBiomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain.
Francesco LandiFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Emanuele MarzettiFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. emanuele.marzetti@policlinicogemelli.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present study examined the associations between malnutrition and physical function, sarcopenia, and frailty in older adults.

methodsThis was a prospective cohort study of octogenarians who lived in the mountain community of the Sirente geographic area in Central Italy. Malnutrition was operationalized according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. Physical performance measures included the short physical performance battery (SPPB) and the isometric handgrip (IHG) test. Sarcopenia was operationalized as the coexistence of dynapenia and low appendicular skeletal mass, while frailty was identified using a modified Fried’s frailty phenotype. Linear regressions were conducted to examine the associations between malnutrition and physical performance tests. Binary regressions were performed to test the associations between malnutrition and both sarcopenia and frailty.

resultsData of 364 older adults (mean age: 86.3 years) were analyzed. Malnutrition was significantly and inversely associated with IHG and walking speed (WS) performance, but not with other physical performance measures. No significant associations were found with sarcopenia or frailty.

conclusionsOur results indicate that malnutrition is significantly associated with impairments in IHG and WS performance, but not with other well-established physical performance tests in octogenarian older adults. These data might be more closely associated with overall health impairments rather than isolated deficits in the neuromuscular system. Moreover, no significant associations were found between malnutrition and the prevalence of sarcopenia or frailty, which might reflect the fact that individuals examined in the present study were in a process of transition.

Indexed as

Frail ElderlyFrailtyMalnutritionPhysical Functional PerformanceSarcopeniaAged, 80 and overCohort StudiesFemaleGeriatric AssessmentHand StrengthHumansItalyMaleProspective StudiesDynapeniaMuscle atrophyOctogenariansPhysical functionUndernutrition

Identifiers

PMID40790463
PMCPMC12337416

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.