Evidence map›Paper›PMID 40790299›Full record

ArticleNature communications2025

Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex.

Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. A biased allosteric modulator functions as a molecular glue to induce βbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yang Yue *iHuman Institute, ShanghaiTech University, Shanghai, China.
Chanjuan Xu *Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.ORCID http://orcid.org/0000-0002-5640-1896
Lijie Wu *iHuman Institute, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-2253-0497
Man NaiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0009-0002-8892-7881
Kexin XuiHuman Institute, ShanghaiTech University, Shanghai, China.
Xuan ChenKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Yuxuan SongKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Sichun WengKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Lu XuiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0009-0007-4481-3125
Fei LiiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-4991-0043
Xi LiniHuman Institute, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-9712-1882
Arthur WangJiKang Therapeutics, Shanghai, China.
Jianfeng LiuKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China. jfliu@mail.hust.edu.cn.ORCID http://orcid.org/0000-0002-0284-8377
Fei XuiHuman Institute, ShanghaiTech University, Shanghai, China. xufei@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0003-0719-3901

Funding

National Natural Science Foundation of China (National Science Foundation of China) W2412030
6 · The paper itself

Abstract

The apelin receptor (APJR) plays a pivotal role in regulating cardiovascular and metabolic health

Indexed as

Apelin Receptorsbeta-Arrestin 1Signal TransductionApelinbeta-ArrestinsHEK293 CellsHumansLigandsProtein BindingApelinApelin ReceptorsAPLNR protein, humanbeta-Arrestin 1beta-ArrestinsLigands

Identifiers

PMID40790299
PMCPMC12339924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.