Evidence map›Paper›PMID 40790272›Full record

ArticleNature medicine2025

Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results.

Zev A Wainberg, Colin D Weekes, Muhammad Furqan, Pashtoon M Kasi, Craig E Devoe, Alexis D Leal, Vincent Chung, James R Perry, Thian Kheoh, Lisa K McNeil and 5 more

Abstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  9. Therapeutic vaccines for NSCLC: From mechanisms to clinical translation.Chinese medical journal pulmonary and critical care medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zev A WainbergUniversity of California, Los Angeles, Los Angeles, CA, USA. zwainberg@mednet.ucla.edu.
Colin D WeekesMassachusetts General Hospital, Boston, MA, USA.
Muhammad FurqanUniversity of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-3137-2053
Pashtoon M KasiUniversity of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-5169-7085
Craig E DevoeNorthwell Health, Lake Success, NY, USA.ORCID http://orcid.org/0000-0002-2290-1884
Alexis D LealUniversity of Colorado School of Medicine, Aurora, CO, USA.
Vincent ChungCity of Hope, Duarte, CA, USA.
James R PerryElicio Therapeutics, Boston, MA, USA.
Thian KheohElicio Therapeutics, Boston, MA, USA.
Lisa K McNeilElicio Therapeutics, Boston, MA, USA.
Esther WelkowskyElicio Therapeutics, Boston, MA, USA.
Peter C DeMuthElicio Therapeutics, Boston, MA, USA.
Christopher M HaqqElicio Therapeutics, Boston, MA, USA. chris.haqq@elicio.com.ORCID http://orcid.org/0000-0001-8600-9548
Shubham Pant *University of Texas MD Anderson Cancer Center, Houston, TX, USA. spant@mdanderson.org.ORCID http://orcid.org/0000-0001-9281-480X
Eileen M O'Reilly *Memorial Sloan Kettering Cancer Center, New York City, NY, USA. oreillye@mskcc.org.ORCID http://orcid.org/0000-0002-8076-9199

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA086862
6 · The paper itself

Abstract

Cellular immunity, mediated by tumor antigen-specific CD4

Indexed as

Cancer VaccinesColorectal NeoplasmsLymph NodesPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)AdultAgedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHumansMaleMiddle AgedMutationCancer VaccinesKRAS protein, humanProto-Oncogene Proteins p21(ras)

Identifiers

PMID40790272
PMCPMC12618236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.