ArticleNature neuroscience2025
Differential kinematic coding in sensorimotor striatum across behavioral domains reflects different contributions to movement.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Continuous contributions of the dorsolateral striatum to movement initiation and execution.Science advances · 2026Article
- Signatures of Covert Neuron Loss in the Local Field Potential of Motor Cortex.Journal of the American Heart Association · 2026Article
- DISSeCT: An unsupervised framework for high-resolution mapping of rodent behavior using inertial sensors.PLoS biology · 2025Article
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8 authors.
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Abstract
The sensorimotor arm of the basal ganglia is a major part of the mammalian motor control network, yet whether it supports all movements or is specialized for task-oriented behaviors remains unclear. To examine this, we probed the contributions of the rat sensorimotor striatum (dorsolateral striatum (DLS)) in two behavioral domains: free exploration, in which naturalistic behaviors are expressed, and during a motor task. In contrast to prior work, which showed the DLS being essential for generating task-specific learned movements, DLS lesions had no effect on naturalistic behaviors like rearing, grooming or walking. To explore the neural basis of this functional dissociation, we compared DLS activity across the two domains. Although neural activity reflected movement kinematics in both, the kinematic codes differed starkly. These findings suggest that sensorimotor basal ganglia are not essential parts of mammalian motor control but, rather, shift their output into a motor-potent space to shape task-specific behaviors.
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