ReviewInternational journal of emergency medicine2025
Neuro-ophthalmology and migraine: visual aura and its neural basis.
Review in International journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Review
- [Migraine aura: differential diagnostics between ophthalmology and neurology].Die Ophthalmologie · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMigraine, a chronic neurological condition often accompanied by visual aura, which affects 15-33% of migraineurs, often presents as transient visual disturbances such as scintillating scotoma and teichopsia. These symptoms arise primarily from cortical spreading depression (CSD) within the occipital cortex and significantly impacts the quality of life, with chronic and episodic migraineurs consistently scoring lower scores in vision-specific quality of life questionnaires. Therefore, this narrative review explores the pathophysiology pertaining to visual aura in migraines, focusing on the role of CSD while evaluating current diagnostic and therapeutic approaches employed.
methodsA narrative literature review was conducted using PubMed and ScienceDirect, focusing on studies published between 2000 and 2025. Search terms related to "migraine", "visual aura", and "cortical spreading depression" were used to identify relevant original research, reviews, and clinical studies addressing the pathophysiology, diagnosis, and treatment of migraine-related visual aura.
resultsFindings indicate that CSD drove transient visual symptoms by triggering waves of neuronal depolarization and hypoperfusion in the visual cortex. Contemporaneous treatment modalities target the headache phase of migraine, with limited alternatives for aura-specific intervention.
conclusionAdvancement in neuroimaging and genetic research offer promising avenues for early diagnosis alongside focused therapeutics for migraine with aura. However, current treatment strategies remain largely focused on the headache phase, with limited efficacy for aura-specific symptoms. Future therapeutic approaches targeting cortical spreading depression may offer more precise interventions for managing visual aura in migraine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.