Evidence map›Paper›PMID 40790128›Full record

ArticleScientific reports2025

Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models.

Lorenzo Dondero, Giulia De Negri Atanasio, Erica Lertora, Francesca Tardanico, Ilaria Demori, Pietro Storace, Giorgia Allaria, Francesca Rispo, Federica Robino, Elisabetta Perata and 3 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lorenzo Dondero *Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Giulia De Negri Atanasio *Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Erica LertoraDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Francesca TardanicoDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Ilaria DemoriDepartment of Pharmacy, University of Genoa, Viale Cembrano 4, Genova, 16148, Italy.
Pietro StoraceDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Giorgia AllariaDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Francesca RispoDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Federica RobinoDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Elisabetta PerataDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Matteo Zanotti-RussoAngel Consulting, Via San Senatore 14, Milano, 20122, Italy.
Sara FerrandoDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy.
Elena GrasselliDepartment of Earth, Environment and Life Science, University of Genoa, Genova, Italy. elena.grasselli@unige.it.

Funding

European Commission 101036428
6 · The paper itself

Abstract

The use of collagen as an active ingredient in cosmetic products is becoming increasingly common. Recently, scientific interest has been focused on fish collagen, which is similar to human collagen and can be extracted from fish by-products. This study evaluates the cosmetic potential of Hydrolyzed Fish Collagen (HFC), testing it both as an aqueous solution (S-HFC) and as a formulation in cosmetic products (F-HFC) containing the same amount of HFC. The effects of S-HFC and F-HFC were evaluated on 2D (endothelial and keratinocyte cells) and 3D (EpiDerm and EpiDerm-FT) skin models. The results demonstrated that HFC, as an active ingredient, shows promising effects on skin physiology, including increased cell viability, enhanced wound healing, and an anti-wrinkle effect.

Indexed as

CollagenDermisSkinAnimalsCell SurvivalCosmeticsEndothelial CellsFishesHumansHydrolysisKeratinocytesSkin AgingWound HealingCollagenCosmeticsCircular economyHydrolyzed fish collagenNew approach methodologiesNext generation risk assessmentSkin ageing

Identifiers

PMID40790128
PMCPMC12340049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.