Evidence map›Paper›PMID 40790086›Full record

ArticleCancer gene therapy2025

METTL3 facilitates colorectal cancer growth through altering the abundance of intestinal Akkermansia muciniphila.

Ling Wu, Weidong Lian, Rui Bai, Hao Chen, Jianghua Wu, Hanyu Li, Liang Zhao

Abstract read
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In one paragraph

Article in Cancer gene therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ling Wu *Department of Pathology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, China.
Weidong Lian *Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Rui Bai *Department of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Hao ChenDepartment of Pathology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, China.
Jianghua WuDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Hanyu LiDepartment of Pathology, The First Affiliated Hospital of Xinxiang University, Xinxiang, China.
Liang ZhaoDepartment of Pathology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, China. liangsmu@foxmail.com.ORCID http://orcid.org/0000-0002-1429-0884

Funding

China Postdoctoral Science Foundation 2022M721540Guangzhou Municipal Science and Technology Project 2024A04J6605National Natural Science Foundation of China (National Science Foundation of China) 82203607Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2021A1515111186
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a prevalent malignant tumor that poses a significant threat to human health; however, the precise mechanism underlying its onset remains elusive. In this study, we utilized metagenomic sequencing to reveal the dysregulation of intestinal microbiota caused by CRC. Single-cell sequencing data showed elevated mRNA expression of methyltransferase-like protein 3 (METTL3) in CRC, which was correlated with the abundance of intestinal microbiota. Furthermore, we found that METTL3 promotion of CRC progression is microbiota-dependent. Using induced METTL3

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeMethyltransferasesAkkermansiaAnimalsCell Line, TumorHumansMiceMethyltransferasesMETTL3 protein, human

Identifiers

PMID40790086

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.