ArticleScientific reports2025
Sleep patterns, plasma metabolites, and risk of incident osteoarthritis: a prospective cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Multi-Trajectories of Sleep Disturbance and Depressive Symptoms and Incident Osteoarthritis: Evidence From the English Longitudinal Study of Ageing.Brain and behavior · 2026Article
- Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival.Clinical and translational medicine · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Although previous studies have assessed the effect of sleep traits on osteoarthritis (OA) risk, the association between the complex interplay of multiple sleep patterns and OA risk remains uncertain. We included participants who were free of OA at baseline based the UK Biobank. We evaluated the associations of five sleep behaviors with the risk of OA using Cox proportional hazard regression models. To explore the metabolic profile of sleep patterns, we regressed the sleep score on 167 standardized metabolites using ten iterations of LASSO model with ten-fold cross-validation. Restricted cubic splines (RCS) with four knots were used in the fully adjusted model to explore the potential non-linear association of sleep score and metabolic profile with OA risk. We discovered that individuals with poor sleep patterns experienced a notably higher incidence of OA (HR, 1.23, 95% CI, 1.18 to 1.28, P = 2.69 × 10
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