Evidence map›Paper›PMID 40790041›Full record

ArticleScientific reports2025

Long intergenic non-coding RNA 00511 (LINC00511) genetic variations and haplotype implication for colorectal cancer susceptibility and prognosis.

Eman F Sanad, Ahmad A Hady, Mohamed Ali, Shorouk Eldash, Nermeen H Elmorshedy, Farah Ayman, Hams M Khattab, Amr Maher, Hadeel Ashree, Mahitab Abdelhady and 7 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Eman F SanadBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt. dr.emansanad@pharma.asu.edu.eg.ORCID http://orcid.org/0000-0001-5406-2029
Ahmad A HadyDepartment of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
Mohamed AliClinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Shorouk EldashPharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), ElSherouk, Cairo, 11837, Egypt.
Nermeen H ElmorshedyDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Farah AymanDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Hams M KhattabDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Amr MaherDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Hadeel AshreeDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Mahitab AbdelhadyDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Mazen MohamedDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Ahmed AdelDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Sajed KhalilDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Omar AlyanDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Ahmed SamirDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Alhassan A BakrDrug Design Program Graduation Project Students, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Nadia M HamdyBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt. nadia_hamdy@pharma.asu.edu.eg.ORCID http://orcid.org/0000-0003-2105-107X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long intergenic non-coding RNA 00,511 (LINC00511) is considered an oncogene for various cancers. However, the association between LINC00511 single nucleotide polymorphisms (SNPs) and colorectal cancer (CRC) remains unclear. Our study aims to study whether LINC00511 SNPs could predict CRC susceptibility or prognosis, an important step-toward precision-health, based on an Egyptian CRC patient cohort. A total of 200 CRC patients and 200 cancer-free controls were genotyped for three LINC00511 SNPs - rs9906859, rs1558535, and rs17780195 using qRT-PCR. Studied SNPs were in strong linkage disequilibrium and moderately correlated in all groups. Genotype association concerning tumor stage, revealed rs1558535 AT and rs17780195 AG variants correlated significantly with CRC advanced stages (adjusted OR: 3.99 and 2.72), respectively. Logistic regression showed that rs1558535 and rs9906859 genotypes were associated with CRC. Haplotype analysis disclosed that 'T

Indexed as

Colorectal NeoplasmsGenetic Predisposition to DiseaseHaplotypesPolymorphism, Single NucleotideRNA, Long NoncodingAdultAgedCase-Control StudiesFemaleGenotypeHumansLinkage DisequilibriumMaleMiddle AgedPrognosisRNA, Long NoncodingColorectal cancer (CRC)Long intergenic non-coding RNA 005 (LINC00511)Single nucleotide polymorphism (SNPs)

Identifiers

PMID40790041
PMCPMC12339720

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.