Evidence map›Paper›PMID 40789993›Full record

ArticleAnnals of surgical oncology2025

Comparing Survival Differences between Patients Undergoing Breast-Conserving Therapy Versus Total Mastectomy as a First Treatment for Early Stage Breast Cancer.

Min Yi, Mariana Chavez-MacGregor, Benjamin D Smith, Melissa P Mitchell, Abigail S Caudle, Sarah M DeSnyder, Henry M Kuerer, Kelly K Hunt

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Min YiUnit 1434, Breast Surgical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mariana Chavez-MacGregorBreast Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Benjamin D SmithRadiation Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Melissa P MitchellRadiation Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Abigail S CaudleUnit 1434, Breast Surgical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sarah M DeSnyderUnit 1434, Breast Surgical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Henry M KuererUnit 1434, Breast Surgical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kelly K HuntUnit 1434, Breast Surgical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. khunt@mdanderson.org.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
CCR NIH HHS CA16672NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate trends in the total mastectomy (TM) rates in patients with early stage breast cancer (BC) undergoing surgery first at a single institution and compare overall (OS), distant metastasis-free (DMFS), local-regional recurrence (LRR), and BC-specific (BCSS) survival between lumpectomy followed by radiation (breast-conserving therapy (BCT)) and TM. PATIENTS AND

methodsA total of 8967 women with clinical stage T1-2, N0-1, M0 BC who underwent upfront surgery from 1 January 2000 to 31 December 2014 were included. TM rates were evaluated. Inverse probability weighting (IPW) based on propensity scores was used to remove confounding in the survival models in the whole cohort and subset analyses (different stage combined with different hormone receptor status).

resultsTM rates increased from 39.7 to 59.9% (P < 0.001) in patients aged ≤ 50 years from 2005 to 2013. At a median follow-up of 6.1 years, after IPW adjustment, patients undergoing BCT or TM with radiation had slightly worse BCSS and similar OS, DMFS, and LRR rates compared with patients who underwent TM alone in the whole cohort. In subset analyses, after IPW adjustment, there were no significant survival differences in OS, BCSS, and DMFS between patients who underwent TM without radiation versus BCT. Among patients with triple-negative BC and stage I disease, those who underwent BCT had a lower LRR rate than those undergoing TM (relative risk (RR), 0.5; P = 0.02).

conclusionsOur study shows that BCT and TM are equivalent as an initial surgical strategy for patients with early stage breast cancer. These data may help physicians in decision-making for patients who are candidates for either TM or BCT.

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularMastectomyMastectomy, SegmentalMastectomy, SimpleNeoplasm Recurrence, LocalAdultAgedFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesBreast-conserving therapyEarly stage breast cancerSurgery firstSurvivalTotal mastectomy

Identifiers

PMID40789993
PMCPMC12352611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.