Evidence map›Paper›PMID 40789963›Full record

ReviewOrthopadie (Heidelberg, Germany)2025

[What does pain have to do with neuronal networks and the afferent matrix?]

Hans-Georg Schaible

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Orthopadie (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Hans-Georg SchaibleInstitut für Physiologie 1/Neurophysiologie, Universitätsklinikum Jena, Teichgraben 8, 07743, Jena, Deutschland. Hans-Georg.Schaible@med.uni-jena.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Harmful (noxious) stimuli and many diseases cause pain. The pain described can reflect the nociception, i.e., the coding of the noxious stimulus or the pathological process. In many cases, however, this is not the case, especially if the pain lasts for along time. For this reason, it is important to understand pain in a broader sense as an expression of brain activity that also expresses other experiences in addition to nociception. This article describes the brain network which, according to our current understanding, generates the subjective sensation of pain. In addition to the areas of the brain that encode noxious stimuli, neuronal circuits of the limbic system, which evaluate the stimuli affectively and emotionally and are involved in response selection, are becoming important. Taking into account the complex neuronal mechanisms of pain development can contribute to better diagnostics and therapy.

Indexed as

Afferent PathwaysBrainNerve NetNociceptionPainHumansLimbic SystemAmygdalaChronic painLimbic systemNociceptionNociceptive neurons

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.