Evidence map›Paper›PMID 40789910›Full record

ArticleScientific reports2025

Extremely low-frequency electromagnetic fields facilitate proliferation and functional differentiation in spinal neural stem cells.

Wenxu Tang, Dan He, Xiaofei Li, Yi Feng, Yue Xu, Jiawei Hu, Wei Xu, Lei Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenxu TangDepartment of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Dan HeInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, 200092, China.
Xiaofei LiDepartment of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Yi FengDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China.
Yue XuDepartment of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Jiawei HuDepartment of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Wei XuDivision of Spine, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. david_xuwei@tongji.edu.cn.
Lei XueDepartment of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, 200438, China. lxue@fudan.edu.cn.

Funding

National Key Research and Development Program of China 2022YFC3602700&2022YFC3602702National Natural Science Foundation of China 32170688Science and Technology Innovation 2030 - Brain Science and Brain-Inspired Intelligence Project 2021ZD0201301Shanghai Municipal Science and Technology Major Project 2018SHZDZX01Shanghai Songjiang District Science and Technology Research Project 22SJKJGG5
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI), typically resulting from direct mechanical damage to the spine, often leads to disruption of neural signaling and axonal conduction, severely impairing nervous system function. In rodent models of SCI, neural stem cell (NSC) transplantation has demonstrated significant potential in restoring motor function and enhancing neural repair. Additionally, extremely low-frequency electromagnetic fields (ELF-EMFs) have demonstrated efficacy in promoting nerve regeneration and activating spinal circuits. However, studies exploring how ELF-EMFs influence NSC activation remain limited. In this study, using spinal cord-derived NSCs from adult mice, we report that ELF-EMFs enhance cell proliferation and self-renewal by upregulating Sox2 expression. Furthermore, we addressed the underlying mechanisms and found that ELF-EMFs activate T-type calcium channels and enhance calcium currents. The resulting increase in intercellular calcium concentration upregulates the expression of NeuroG1 and NeuroD1, promoting neuronal differentiation of NSCs and enhancing neurite outgrowth. Our findings provide new insights into the ELF-EMF-mediated activation of NSCs and highlight their potential for integration into combination therapies and SCI repair.

Indexed as

Cell DifferentiationCell ProliferationElectromagnetic FieldsNeural Stem CellsSpinal CordSpinal Cord InjuriesAnimalsBasic Helix-Loop-Helix ProteinsCalciumCalcium Channels, T-TypeMiceNerve Tissue ProteinsSOXB1 Transcription FactorsBasic Helix-Loop-Helix ProteinsCalciumCalcium Channels, T-TypeNerve Tissue ProteinsNeurog1 protein, mouseSox2 protein, mouseSOXB1 Transcription FactorsCell differentiationCell proliferationExtremely low-frequency electromagnetic fieldsPro-neuronal geneSpinal cord-derived neural stem cellsSpinal cord injury

Identifiers

PMID40789910
PMCPMC12339996

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.