ArticleScientific reports2025
Exploring the application value of ultrasound in animal studies of stem cell therapy for intrauterine adhesions.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Hydrogel-Based Systems in Intrauterine Adhesions: Bridging the Gap from Bench to Bedside.Advanced healthcare materials · 2026Review
- [Current status of intrauterine adhesion treatment and research progress in stem cell therapy].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Endometrial damage leads to intrauterine adhesions (IUA), significantly impairing endometrial receptivity and fertility. Stem cell therapies, particularly umbilical cord mesenchymal stem cell (UC-MSCs), have shown promise in regenerating damaged endometrium, but prior studies have relied on ex vivo pathological evaluations. Ultrasound, as a non-invasive examination method, provides an important basis for the diagnosis, treatment and prognostic assessment of uterine adhesions in clinical practice. A series of statistical techniques were systematically used in this study, one-way ANOVA test, LSD-t test, Mann Whitney U test, Dunn's t test, and linear regression, with the aim of investigating whether ultrasound can effectively assess the effect of rat IUA model after treatment with IUA. This was an animal study involving 30 female Sprague-Dawley rats randomly divided into three groups: normal (n = 10), IUA model (n = 10), and UC-MSC therapy (n = 10). The study duration was approximately three months, including UC-MSC administration and post-treatment follow-up. IUA was induced in the model and UC-MSC groups by mechanical scraping of the uterine endometrium. Rats in the UC-MSC group received intrauterine infusions of UC-MSCs. Endometrial thickness, morphology, and continuity were evaluated pre- and post-treatment using ultrasound. Histological analysis, including H&E, Masson's staining, and CK immunohistochemistry, was performed after euthanasia. Endometrial thickness significantly increased in the UC-MSC group compared to the model group (0.34 ± 0.06 mm vs. 0.11 ± 0.03 mm, p < 0.05), while fibrosis was significantly reduced (15.11% vs. 28.14%, p < 0.05). The UC-MSC group exhibited improved endometrial morphology and glandular density compared to the model group (p < 0.05). Particularly Ultrasound findings of endometrial thickness, are significantly associated with pathological assessments (r > 0.99, p < 0.0001). This study demonstrates that ultrasound is a reliable, non-invasive tool for monitoring the therapeutic effects of UC-MSCs on endometrial regeneration in vivo.
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