Evidence map›Paper›PMID 40789848›Full record

ArticleNature communications2025

An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting.

Evelyn M Kimbrough, Ha An Nguyen, Haixing Li, Jacob M Mattingly, Nevette A Bailey, Wei Ning, Howard Gamper, Ya-Ming Hou, Ruben L Gonzalez, Christine M Dunham

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Recoding by NNature communications · 2026
    Article
  2. tRNA modifications in viral replication.The Journal of biological chemistry · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Evelyn M KimbroughDepartment of Chemistry, Emory University, Atlanta, GA, USA.
Ha An NguyenDepartment of Chemistry, Emory University, Atlanta, GA, USA.
Haixing LiDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-1383-4907
Jacob M MattinglyDepartment of Chemistry, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-0202-915X
Nevette A BaileyDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID http://orcid.org/0009-0000-3107-0640
Wei NingDepartment of Chemistry, Columbia University, New York, NY, USA.
Howard GamperDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-9007-8546
Ya-Ming HouDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6546-2597
Ruben L GonzalezDepartment of Chemistry, Columbia University, New York, NY, USA. rlg2118@columbia.edu.ORCID http://orcid.org/0000-0002-1344-5581
Christine M DunhamDepartment of Chemistry, Emory University, Atlanta, GA, USA. christine.m.dunham@emory.edu.ORCID http://orcid.org/0000-0002-8821-688X

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
tRNA in codon usageR35GM134931 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2020 to 2025
$5.4M
Structural Studies of Ribosome RegulationR01GM093278 · NIGMS · EMORY UNIVERSITY · PI DUNHAM, CHRISTINE M · 2010 to 2022
$4.6M
The Structural Dynamics of Translation and Translational ControlR35GM153724 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Ruben L Gonzalez · 2024 to 2026
$2.4M
The structural dynamics of translation elongation and its regulationR01GM119386 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GONZALEZ, RUBEN L · 2016 to 2019
$1.3M
Ribosome regulation, inhibition, and quality control mechanismsR35GM156629 · NIGMS · EMORY UNIVERSITY · PI Christine M Dunham · 2025 to 2026
$899k
NIGMS NIH HHS R01 GM093278NIGMS NIH HHS R01 GM119386NIGMS NIH HHS R35 GM134931NIGMS NIH HHS R35 GM153724NIGMS NIH HHS R35 GM156629NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

RNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute to tRNA stability and accurate protein synthesis. Absence of such modifications causes translation errors, including mRNA frameshifting. By integrating single-molecule fluorescence resonance energy transfer and cryogenic electron microscopy, we demonstrate that the N

Indexed as

AnticodonCodonEscherichia coliFrameshifting, RibosomalRNA, TransferBase PairingCryoelectron MicroscopyFluorescence Resonance Energy TransferGuanosineNucleic Acid ConformationProtein BiosynthesisRibosomesRNA, BacterialRNA, MessengerRNA Processing, Post-TranscriptionalAnticodonCodonGuanosineRNA, BacterialRNA, MessengerRNA, Transfer

Identifiers

PMID40789848
PMCPMC12340085

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.