Evidence map›Paper›PMID 40789831›Full record

GuidelineJournal of anesthesia2025

Executive summary of the guideline for prescribing opioid analgesics for chronic non-cancer pain (third edition) by the Japan Society of Pain Clinicians.

Akifumi Kanai, Masako Iseki, Hiroki Iida, Shigeki Yamaguchi, Ayano Oiwa, Hiroshi Yonekura, Narihito Iwashita, Hiroshi Ueno, Yoshiyuki Kimura, Toshifumi Takasusuki and 12 more

Abstract readConsensus StatementPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Journal of anesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Akifumi KanaiDivision of Dolorology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, 1-15-1 Kitazato, Minami-ku, Sagamihara City, Kanagawa Prefecture, 252-0374, Japan. kanai@med.kitasato-u.ac.jp.ORCID http://orcid.org/0000-0002-1864-3632
Masako IsekiDepartment of Anesthesiology and Pain Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Hiroki IidaAnesthesiology and Pain Relief Center, Central Japan International Medical Center, Minokamo, Japan.
Shigeki YamaguchiDepartment of Anesthesiology, Dokkyo Medical University School of Medicine, Mibu, Japan.
Ayano OiwaDepartment of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
Hiroshi YonekuraDepartment of Anesthesiology and Pain Medicine, Fujita Health University Bantane Hospital, Nagoya, Japan.
Narihito IwashitaPain Management Clinic, Shiga University of Medical Science Hospital, Otsu, Japan.
Hiroshi UenoDepartment of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yoshiyuki KimuraDepartment of Anesthesiology, Dokkyo Medical University School of Medicine, Mibu, Japan.
Toshifumi TakasusukiDepartment of Anesthesiology, Dokkyo Medical University School of Medicine, Mibu, Japan.
Keisuke YamaguchiDepartment of Anesthesiology and Pain Medicine, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Shie IidaDepartment of Anesthesiology and Pain Medicine, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Hiroko IkemiyaDepartment of Anesthesiology and Pain Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Rina OyaDepartment of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yoko SugiyamaAnesthesiology and Pain Relief Center, Central Japan International Medical Center, Minokamo, Japan.
Kumiko TanabeDepartment of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Ayano TaniguchiDepartment of Palliative Medicine, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
Yoshiyasu HattammaruDepartment of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
Maki MizogamiAnesthesiology and Pain Relief Center, Central Japan International Medical Center, Minokamo, Japan.
Shinobu YamaguchiYoshimura Pain Clinic, Gifu, Japan.
Keiko YamadaDepartment of Anesthesiology and Pain Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Sei FukuiDepartment of Advanced Pain Medicine, Aichi Medical University, Nagakute, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid analgesics are powerful pain relievers, but inappropriate use can cause a variety of problems. Especially, in chronic non-cancer pain, inappropriate use of opioid analgesics might fail to improve or even worsen the quality of life and activities of daily living of patients impaired by pain. The Japan Society of Pain Clinicians has developed the Guidelines for Prescribing Opioid Analgesics for Chronic Non-cancer Pain (Third Edition), which answers basic clinical questions concerning opioid management as summary statements in accordance with the most recent scientific evidence and expert opinion. The guidelines emphasize patient selection (e.g., obvious organic cause of the persistent pain, low risk of psychosocial factors, pain refractory to non-opioid therapies, and good adherence to medication). Furthermore, patients should be treated with an oral dose of 90 morphine milligram equivalents/day as the upper limit and target duration of 3-6 months. For pain in cancer survivors that is not directly caused by cancer, such as pain after treatment or pain associated with complications or pre-existing conditions, these guidelines should be followed.

Indexed as

Analgesics, OpioidChronic PainPain ManagementHumansJapanPatient SelectionSocieties, MedicalAnalgesics, OpioidChronic painJapanese guidelineNon-cancer painOpioid analgesics

Identifiers

PMID40789831
PMCPMC12464052

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.