Trial reportClinical oral investigations2025
Clinical, radiographic and molecular efficacy of LLLT along with minimally invasive flaps in regeneration of periodontal intrabony defects: a randomized controlled clinical trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Use of Laser in Periodontal Tissue Regeneration: A Scoping Review of Clinical and Experimental Evidence.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe current study evaluates the effectiveness of low level laser therapy (LLLT) in intra-bony defect regeneration, by comparing the clinical, radiographic and molecular parameters between periodontitis patients with intra-bony defects treated with simplified papilla preservation flap(SPPF) alone and SPPF with adjunctive use of LLLT. METHODOLOGY: The current study is a randomized controlled clinical trial involving 64 sites, 32 sites treated with SPPF- control group and 32 sites treated with SPPF and adjunctive use of LLLT(SPPF + LLLT)- test group. Clinical parameters were evaluated at baseline, 6 months and 1 year post surgery. Radiographic defect depths were evaluated at baseline and 1 year post surgery. Molecular parameters- RUNX2, BMP-2, osteopontin and COL-1 are evaluated at 3, 7 and 14 days. The results were statistically analysed.
resultsThere was a statistically significant reduction in clinical parameters and radiographic defect depth seen in test group at the 6 months and one year post surgery when compared with control group (P < 0.05). In addition, the total number of sites with probing pocket depth more than 4 mm has reduced significantly in test group when compared to control group at 6 months and one year. RUNX2, BMP-2 and COL - 1 were significantly elevated in test group.
conclusionThe current study reports a significant improvement of clinical, radiographic and molecular parameters of intra-bony defect sites in periodontitis patients treated with SPPF + LLLT when compared to SPPF alone.
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Registered trials
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