Evidence map›Paper›PMID 40789809›Full record

ArticleThe international journal of cardiovascular imaging2025

Ventricular blood T2 in asymptomatic adults at 3T: effect of age and lung volume by magnetic resonance imaging.

Chia-Ying Liu, Chikara Noda, Bharath Ambale-Venkatesh, Yoko Kato, Yoshimori Kassai, David A Bluemke, Aparna Balasubramanian, João A C Lima

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Article in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chia-Ying LiuCanon Medical Systems Corporation, 1385 Shimoishigami, Otawara-shi, 324-8550, Tochigi, Japan. cliu@mru.medical.canon.
Chikara NodaDivision of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Bharath Ambale-VenkateshDivision of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Yoko KatoDivision of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Yoshimori KassaiCanon Medical Systems Corporation, 1385 Shimoishigami, Otawara-shi, 324-8550, Tochigi, Japan.
David A BluemkeDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Aparna BalasubramanianDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
João A C LimaDivision of Cardiology, Johns Hopkins University, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the normal ranges of myocardial T1 and T2 have been vastly reported, the studies on blood T2 are limited and data is sparse. The purpose of this study was to report the age and sex distribution of right (RV) and left ventricular (LV) blood T2 in the human heart and to evaluate their relationships to lung volume. 156 asymptomatic adults without hypertension or diabetes and free from cardiopulmonary disease (74 men, mean age 50 ± 14 years, range 24-81 years) were included. 3T MRI including cardiac scout and T2-prepared gradient-echo sequence for T2 mapping were acquired with breath hold in the resting lung position (i.e. functional residual capacity, FRC). T2 maps were used to measure blood T2 times. MRI-estimated FRC (MRI-eFRC) was measured using a single scout image in the coronal orientation and was assessed by delineation of the chest wall manually excluding the heart. Men had higher MRI-eFRC (p = 0.002) and LV blood T2 (99 ± 24 ms vs. 91 ± 21 ms, p = 0.03) than women but RV blood T2 were similar (81 ± 12 ms vs. 78 ± 11 ms, p = 0.2). Both MRI-eFRC (r = 0.17, p = 0.04) and LV blood T2 (r = 0.33, p < 0.0001) were positively correlated with age, while RV blood T2 did not show age dependence. MRI-eFRC was also positively correlated with LV blood T2 (r = 0.18, p = 0.02) but not with RV blood T2. Ventricular T2 values exhibited good intra- and inter-observer reproducibility (coefficient of variation < 3%). Our study provides the normal ranges of ventricular blood T2 relaxation times in sex and age groups using the T2-prepared gradient echo sequence at 3T and demonstrated that LV blood T2 is positively associated with age, which may serve as a basis for future studies for clinical CMR examination involving patients with diseases altering these parameters.

Indexed as

AgingLungLung Volume MeasurementsMagnetic Resonance ImagingVentricular Function, LeftVentricular Function, RightAdultAgedAged, 80 and overAge FactorsAsymptomatic DiseasesFemaleHumansMaleMiddle AgedPredictive Value of TestsBlood T2Functional residual capacityT1 mappingT2 mapping

Identifiers

PMID40789809

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.