ArticleNeurocritical care2025
N20-P25 Amplitude can Predict Awakening from Coma.
Article in Neurocritical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Prognostic value of auditory evoked potentials in disorders of consciousness: a systematic literature review.Clinical neurophysiology practice · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe objective of this study was to evaluate the relationship between the N20-P25 amplitude of short-latency somatosensory evoked potentials (SSEPs) and neurologic outcomes in patients in a coma state.
methodsWe retrospectively enrolled neurocritical patients who were older than 18 years; were admitted to the Department of Critical Medicine, Xiangya Hospital, Central South University, from January 2017 to January 2021 for 1-3 days; had a Glasgow Coma Scale score ≤ 8; had a body temperature ≥ 35 °C; and had SSEP records. Good outcome was defined as Cerebral Performance Category scores 1-3 at 1 year. The specificity and sensitivity of different SSEP patterns and amplitudes were calculated.
resultsA total of 457 patients were included in this study. The N20-P25 amplitude can be used for predicting awakening for traumatic brain injury (TBI) (area under the curve [AUC] 0.70, p = 0.0077), aneurysmal subarachnoid hemorrhage (SAH) (AUC 0.69, p = 0.005), intracerebral hemorrhage (ICH) (AUC 0.69, p = 0.005), and cardiac arrest (CA) (AUC 0.72, p = 0.0077). An N20-P25 amplitude > 1.6 μV predicted awakening in CA, with a sensitivity of 100% (95% confidence interval [CI] 81.6-100%) and specificity of 46.7% (95% CI 30.9-60.9%). In SAH, an N20-P25 amplitude > 0.74 μV predicted the sensitivity and specificity of awakening were 100% (95% CI 93.8-100%) and 16% (95% CI 8.3-28.5%), respectively. In TBI, an N20-P25 amplitude > 1.20 μV predicted awakening with a sensitivity of 100% (95% CI 86.2-100%) and a specificity of 34.2% (95% CI 21.2-50.1%). An N20-P25 amplitude > 0.65 μV predicted the sensitivity and specificity of awakening in ICH were 100% (95% CI 91.0-100%) and 14.3% (95% CI 5.7-31.5%), respectively.
conclusionsN20-P25 amplitude can predict awakening in patients in a coma state at 1 year. Different diseases have different cutoff values for predicting awakening.
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