Evidence map›Paper›PMID 40789801›Full record

SynthesisAlcohol, clinical & experimental research2025

Behavioral interventions for individuals with fetal alcohol spectrum disorder: A review of systematic reviews.

Eric Flake, Elizabeth H Lee, Kyle Patrick Apilado, Rachel Sayko Adams, Alyssa MacMahon, Tracey Perez Koehlmoos

Abstract readSystematic Review
In one paragraph

Synthesis in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eric FlakeCenter for Health Services Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Elizabeth H LeeCenter for Health Services Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.ORCID 0000-0003-2094-6445
Kyle Patrick ApiladoCenter for Health Services Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.ORCID 0009-0009-7108-8402
Rachel Sayko AdamsDepartment of Health Law, Policy & Management, Boston University School of Public Health, Boston, Massachusetts, USA.
Alyssa MacMahonDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Tracey Perez KoehlmoosCenter for Health Services Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Funding

Defense Health Agency HU00012320112
6 · The paper itself

Abstract

backgroundIndividuals diagnosed under the spectrum of fetal alcohol spectrum disorders (FASD) experience numerous cognitive and behavioral impairments, including learning disabilities, executive functioning dysfunction, and difficulties in emotional regulation. Studies of direct child-centered nonpharmacological behavioral interventions to improve outcomes have steadily developed over the past few decades. Systematic reviews of this literature have documented the wide collection of studies, and an overall review of these reviews permits a single, comprehensive analysis encompassing behavioral intervention research.

methodsElectronic databases were searched for systematic reviews from 2005 to 2024. Included reviews reported the effectiveness of child-centered behavioral, nonpharmacological interventions in noneducational settings for individuals with FASD from birth until the age of 18. Abstract screening, full-text screening, and data extraction were conducted using Covidence. AMSTAR-2 was utilized to assess the methodological quality of systematic reviews.

resultsA total of seven systematic reviews were included for comprehensive analysis. Two reviews were of high quality, two were of low quality, and three were of critically low quality, as per AMSTAR-2 grading criteria. Categories of behavioral interventions within systematic reviews included executive functioning interventions, self-management interventions, social skill interventions, family-based interventions, cognitive behavioral interventions, and applied behavior analysis-based treatment. While numerous positive outcomes were identified across several behavioral interventions, the systematic reviews identified multiple limitations, such as high risk of bias and small sample sizes.

conclusionNumerous positive outcomes were identified from among systematic reviews regarding FASD interventions; however, the current evidence base is limited by methodological weaknesses and potential risks of bias. Further research and implementation are necessary to strengthen the delivery of interventions and continue improving outcomes for individuals with FASD.

Indexed as

Behavior TherapyFetal Alcohol Spectrum DisordersChildCognitive Behavioral TherapyExecutive FunctionFemaleHumansPregnancySystematic Reviews as Topicbehavioral interventionfetal alcohol spectrum disorderreview

Identifiers

PMID40789801
PMCPMC12463752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.