Evidence map›Paper›PMID 40789800›Full record

ArticleOdontology2026

Effect of masseter hypofunction on mandibular growth and masticatory muscle coordination: an in vivo study of animal model.

Kana Yamamoto, Tomoko Yoshimi, Ryo Hamanaka, Kaori Hayashida, Emi Moriuchi, Keiko Yoshimi, Noriaki Yoshida

Abstract read
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In one paragraph

Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kana YamamotoDepartment of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Tomoko YoshimiDepartment of Orthodontics, Nagasaki University Hospital, Nagasaki, Japan.
Ryo HamanakaDepartment of Orthodontics, Nagasaki University Hospital, Nagasaki, Japan.
Kaori HayashidaDepartment of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Emi MoriuchiDepartment of Orthodontics, Nagasaki University Hospital, Nagasaki, Japan.
Keiko YoshimiYoshimi Skin Clinic, Nagasaki, Japan.
Noriaki YoshidaDepartment of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. nori@nagasaki-u.ac.jp.

Funding

Japan Society for the Promotion of Science 9524K13217Japan Society for the Promotion of Science 9524K20114
6 · The paper itself

Abstract

It has been considered that dysfunction of masticatory muscles could affect growth and development of maxillofacial morphology. However, effects of reduced masticatory muscle functions on mandibular growth and changes in the coordination mechanism between individual muscles have not been fully investigated. This study aimed to investigate the association between masticatory function and mandibular growth and then clarify the roles of individual masticatory muscles and their compensation mechanisms. Sixteen general purpose mice received botulinum neurotoxin type A (BoNT⁄A) unilaterally into the right masseter to induce muscle hypofunction, and the left side was used as a control side. Micro-computed tomography was used to evaluate morphometric changes in the mandible at 3 and 9 weeks of age. The amount of growth for each measurement item was obtained by subtracting the measured value at 3 weeks of age from that at 9 weeks of age, and then the results were compared between the BoNT⁄A-injected side and the control side. A paired t-test was used for statistical analysis, and P < 0.05 was considered significant. Growth changes in mandibular body length, condylar width and coronoid process length were significantly smaller on the BoNT⁄A-injected side than on the control side, whereas the change in ramus height was larger on the BoNT⁄A-injected side than on the control side. Mandibular growth was strongly affected by alterations in masticatory function. The present study suggests that the temporalis muscle cannot compensate for hypofunction of the masseter muscle, but the internal pterygoid muscle can.

Indexed as

MandibleMasseter MuscleMasticatory MusclesAnimalsBotulinum Toxins, Type ADisease Models, AnimalMaleMiceX-Ray MicrotomographyBotulinum Toxins, Type ABotulinum neurotoxinHypofunctionMandibular growthMasticationMasticatory muscleMouse

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.