Evidence map›Paper›PMID 40789732›Full record

ArticleBMJ open2025

Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trial.

Tonghu Jin, Hao Niu, Lan Liu, Yunjian Yin, Wenbo Zhao, Xin Feng, Liuyu Xu, David C Hess, Aihua Liu, Xunming Ji

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06711302 (Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06711302 nanot yet recruitingnot on this map

Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage: a Multi-center, Randomized, Double-blind, Sham-controlled, Parallel-group Trial

TypeinterventionalSponsorBeijing Tiantan HospitalRan2025 to 2026Enrolled500ConditionsSubarachnoid Hemorrhage, Cerebrovascular Disorders, Brain Diseases, StrokeArmsSham RIC, Remote Ischemic Conditioning treatment instrument
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tonghu Jin *Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0009-0008-4132-6687
Hao Niu *Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Lan LiuBeijing Institute For Brain Disorders, Beijing, China.
Yunjian YinBeijing Institute For Brain Disorders, Beijing, China.
Wenbo ZhaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xin FengZhujiang Hospital, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0002-4874-8048
Liuyu XuBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
David C HessDepartment of Neurology, Medical College of Georgia, Augusta, Georgia, USA liuaihuadoctor@ccmu.edu.cn DHESS@augusta.edu jixm@ccmu.edu.cn.
Aihua LiuBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China liuaihuadoctor@ccmu.edu.cn DHESS@augusta.edu jixm@ccmu.edu.cn.
Xunming JiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China liuaihuadoctor@ccmu.edu.cn DHESS@augusta.edu jixm@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA large number of basic and clinical studies have demonstrated that remote ischaemic conditioning (RIC) has neuroprotective effects. Recently, RIC has made gratifying progress in the field of ischaemia stroke treatment. A considerable number of basic and clinical studies have also revealed the possible therapeutic effects of RIC on subarachnoid haemorrhage. However, the neuroprotective effect of RIC on subarachnoid haemorrhage is still lacking convincing evidence and deserves further study.

aimTo explore the efficacy and safety of RIC for aneurysmal subarachnoid haemorrhage. METHODS AND ANALYSIS: An investigator-initiated, multicentre, randomised, double-blind, sham-controlled, parallel-group trial to evaluate the effect of RIC intervention compared to sham RIC intervention for the neurological function improvement of patients with aneurysmal subarachnoid haemorrhage. ETHICS AND DISSEMINATION: The protocol was approved by the IRB of Beijing Tiantan Hospital, Capital Medical University (KY2024-080-03). Progress and safety of the trial are monitored by an independent Data and Safety Monitoring Board. Study results will be published in peer-reviewed medical journals. Written informed consent will be obtained from all participants. TRIAL REGISTRATION NUMBER: NCT06711302.

Indexed as

Ischemic PreconditioningSubarachnoid HemorrhageAdultDouble-Blind MethodFemaleHumansMaleMulticenter Studies as TopicRandomized Controlled Trials as TopicTreatment OutcomeBrain InjuriesClinical ProtocolsNeurosurgeryStroke

Identifiers

PMID40789732
PMCPMC12352245

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