Evidence map›Paper›PMID 40789731›Full record

ArticleBMJ open2025

Pragmatic, multicentre, factorial, randomised controlled trial of sepsis electronic prompting for timely intervention and care (SEPTIC trial): a protocol.

Benjamin L Ranard, Min Qian, Matthew J Cummings, David Y Zhang, Shing M Lee, Jeremy R Beitler, Jo R Applebaum, Edward J Schenck, Hassan Mohamed, Richard Trepp and 9 more

2 registry-linked trialsAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06117605 nacompletednot on this map

Protocol for a Pragmatic, Multicenter, Factorial, Randomized Controlled Trial of Sepsis Electronic Prompting for Timely Intervention and Care (SEPTIC Trial) for Emergency Department Patients

TypeinterventionalSponsorColumbia UniversityRan2023 to 2024Enrolled25,668ConditionsSepsis, Electronic Health Records, Clinical Decision Support SystemsArmsNurse SIRS alert, Prescribing clinician SIRS alert
NCT06117618 nacompletednot on this map

Protocol for a Pragmatic, Multicenter, Factorial, Randomized Controlled Trial of Sepsis Electronic Prompting for Timely Intervention and Care (SEPTIC Trial) for Inpatients

TypeinterventionalSponsorColumbia UniversityRan2023 to 2024Enrolled12,284ConditionsSepsis, Electronic Health Records, Clinical Decision Support SystemsArmsNurse SIRS alert, Prescribing clinician SIRS alert
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Benjamin L RanardDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA b.ranard@columbia.edu.ORCID http://orcid.org/0000-0002-9565-6939
Min QianDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, New York, USA.
Matthew J CummingsDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
David Y ZhangNorthwell, New Hyde Park, New York, USA.
Shing M LeeDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, New York, USA.
Jeremy R BeitlerDivision of Pulmonary, Critical Care and Sleep Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Jo R ApplebaumCenter for Patient Safety Science, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Edward J SchenckNewYork-Presbyterian Hospital, New York, New York, USA.ORCID http://orcid.org/0000-0002-7950-5989
Hassan MohamedNewYork-Presbyterian Hospital, New York, New York, USA.ORCID http://orcid.org/0009-0003-1232-597X
Richard TreppNewYork-Presbyterian Hospital, New York, New York, USA.
Hanson HsuNewYork-Presbyterian Hospital, New York, New York, USA.ORCID http://orcid.org/0000-0002-8120-5619
Jean ScofiNewYork-Presbyterian Hospital, New York, New York, USA.
William N SouthernDivision of Hospital Medicine, Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York, USA.
Sarah C RossettiDepartment of Biomedical Informatics, Columbia University, New York, New York, USA.
Natalie H YipDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Daniel BrodieDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Manish SharmaDepartment of Emergency Medicine, NewYork-Presbyterian Queens, Flushing, New York, USA.
Baruch S FertelNewYork-Presbyterian Hospital, New York, New York, USA.
Jason S AdelmanCenter for Patient Safety Science, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID http://orcid.org/0000-0002-7497-257X

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
AHRQ HHS T32 HS026121NCATS NIH HHS UL1 TR001873NCI NIH HHS P30 CA013696
6 · The paper itself

Abstract

introductionSepsis is a major cause of death both globally and in the United States. Early identification and treatment of sepsis are crucial for improving patient outcomes. International guidelines recommend hospital sepsis screening programmes, which are commonly implemented in the electronic health record (EHR) as an interruptive sepsis screening alert based on systemic inflammatory response syndrome (SIRS) criteria. Despite widespread use, it is unknown whether these sepsis screening and alert tools improve the delivery of high-quality sepsis care. METHODS AND ANALYSIS: The Sepsis Electronic Prompting for Timely Intervention and Care (SEPTIC) master protocol will study two distinct populations in separate trials: emergency department (ED) patients (SEPTIC-ED) and inpatients (SEPTIC-IP). The SEPTIC trials are pragmatic, multicentre, blinded, randomised controlled trials, with equal allocation to compare four SIRS-based sepsis screening alert groups: no alerts (control), nurse alerts only, prescribing clinician alerts only, or nurse and prescribing clinician alerts. Randomisation will be at the patient level. SEPTIC will be performed at eight acute-care hospitals in the greater New York City area and enrol patients at least 18 years old. The primary outcome is the percentage of patients with completion of a modified Surviving Sepsis Campaign (SSC) hour-1 bundle within 3 hours of the first SIRS alert. Secondary outcomes include time from first alert to completion of a modified SSC hour-1 bundle, time from first alert to individual bundle component order and completion, intensive care unit (ICU) transfer, hospital discharge disposition, inpatient mortality at 90 days, positive blood cultures (bacteraemia), adverse antibiotic events, sepsis diagnoses and septic shock diagnoses. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Columbia University Institutional Review Board (IRB) serving as a single IRB. Results will be disseminated in peer-reviewed journal(s), scientific meeting(s) and via social media. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT06117605 and NCT06117618.

Indexed as

Electronic Health RecordsSepsisEmergency Service, HospitalHumansMulticenter Studies as TopicPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicClinical TrialEmergency DepartmentsHealth informaticsINTENSIVE & CRITICAL CARERandomized Controlled Trial

Identifiers

PMID40789731
PMCPMC12352262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.