ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Structural Regeneration and Functional Recovery of the Olfactory System of Adult Zebrafish Following Brain Injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Article
- Olfactory Dysfunction in a Novel Model of Prodromal Parkinson's Disease in Adult Zebrafish.International journal of molecular sciences · 2025Article
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9 authors.
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Abstract
Olfactory dysfunction is a common outcome of brain injuries, negatively affecting quality of life. The adult mammalian nervous system has limited capacity for olfactory recovery, making it challenging to study olfactory regeneration and recovery. In contrast, zebrafish are ideal for such studies due to its extensive and lifelong regenerative abilities. In this work, we describe a model of excitotoxic injury in the olfactory bulb (OB) using quinolinic acid lesions in adult zebrafish of both sexes. We observed extensive neurodegeneration in both the OB and olfactory epithelium, including a reduction of bulbar volume, neuronal death, and impaired olfactory function. Recovery mechanisms involved tissue remodeling, cell proliferation, and neurogenesis, leading to full restoration of olfactory function by 21 d. This study provides a model to further investigate the effects of excitotoxicity on olfactory dysfunction and highlights zebrafish's remarkable regenerative abilities, providing insights into potential therapeutic strategies for restoring olfactory function following brain injuries.
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