Evidence map›Paper›PMID 40789653›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Impact of Elovl5 Deficiency on Cerebellar Excitatory Synaptic Transmission in Mice.

Francesca Montarolo, Fangyuan Gao, Matilde Loddo, Jacek Milek, Michalina Zawadzka, Maria Concetta Miniaci, Alfredo Brusco, Ilaria Balbo, Magdalena Dziembowska, Filippo Tempia and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca MontaroloDepartment of Neuroscience, University of Torino, Torino 10125, Italy.
Fangyuan GaoCenter for Translational Vision Research, Department of Ophthalmology, and Visual Sciences, University of California, Irvine, Irvine, California 92697.
Matilde LoddoNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO) 10043, Italy.
Jacek MilekFaculty of Biology, University of Warsaw, Warsaw 02-096, Poland.
Michalina ZawadzkaFaculty of Biology, University of Warsaw, Warsaw 02-096, Poland.
Maria Concetta MiniaciDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Napoli 80131, Italy.
Alfredo BruscoDepartment of Neuroscience, University of Torino, Torino 10125, Italy.ORCID 0000-0002-8318-7231
Ilaria BalboDepartment of Neuroscience, University of Torino, Torino 10125, Italy.
Magdalena DziembowskaFaculty of Biology, University of Warsaw, Warsaw 02-096, Poland.
Filippo TempiaDepartment of Neuroscience, University of Torino, Torino 10125, Italy.ORCID 0000-0003-2778-0943
Dorota Skowronska-KrawczykCenter for Translational Vision Research, Department of Ophthalmology, and Visual Sciences, University of California, Irvine, Irvine, California 92697 eriola.hoxha@unito.it dorotask@hs.uci.edu.
Eriola HoxhaDepartment of Neuroscience, University of Torino, Torino 10125, Italy eriola.hoxha@unito.it dorotask@hs.uci.edu.ORCID 0000-0002-4452-889X

Funding

NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2022 to 2026
$3.7M
Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE)U01EY034594 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SKOWRONSKA-KRAWCZYK, DOROTA, WAHLIN, KARL J · 2022 to 2025
$1.6M
NEI NIH HHS P30 EY034070NEI NIH HHS U01 EY034594
6 · The paper itself

Abstract

The neurotransmitter release and the synaptic vesicle cycle require a specific lipidic composition of presynaptic and vesicle membranes. Phospholipids with long-chain acyl groups are necessary to confer to membranes the physical properties necessary for synaptic transmission. Elovl5 is crucial for the elongation of polyunsaturated fatty acids (PUFAs) beyond 18-carbon atoms, and its deletion or mutation causes cerebellar motor deficits in humans and mice. In the mouse cerebellum of both sexes, deletion of

Indexed as

AcetyltransferasesCerebellumExcitatory Postsynaptic PotentialsSynaptic TransmissionAnimalsFatty Acid ElongasesFatty Acids, UnsaturatedFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPurkinje CellsAcetyltransferasesFatty Acid ElongasesFatty Acids, UnsaturatedcerebellumELOngation of Very Long-chain fatty acid-5excitatory postsynaptic currentpolyunsaturated fatty acidssynaptically induced suppression of excitation

Identifiers

PMID40789653
PMCPMC12444844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.