Evidence map›Paper›PMID 40789626›Full record

ArticleJournal of the American Board of Family Medicine : JABFM2025

Is Cognitive Impairment Associated with Inadequate Bowel Preparation for Colonoscopy?

Jeanette M Daly, Yinghui Xu, Seth D Crockett, Richard M Hoffman, Barcey T Levy

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Board of Family Medicine : JABFM, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03264898 (Comparative Effectiveness of Fecal Immunochemical Tests With Optical Colonoscopy), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03264898 completednot on this map

Comparative Effectiveness of Fecal Immunochemical Tests With Optical Colonoscopy (R01 CA215034)

TypeobservationalSponsorBarcey T. LevyRan2017 to 2023Enrolled3,761ConditionsColorectal CancerArmsFecal immunochemical test (FIT)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The 4Cs of Primary Care, Leveraging Artificial Intelligence, and Improving Clinical Practice.Journal of the American Board of Family Medicine : JABFM · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeanette M DalyFrom the University of Iowa Carver College of Medicine, Iowa City, IA (JMD, YX, RMH, BTL); University of North Carolina School of Medicine, Chapel Hill, NC (SDC); Oregon Health & Science University and Portland VA Medical Center, Portland, OR (SDC); Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA (RMH, BTL); and University of Iowa College of Public Health, Iowa City, IA (BTL). jeanette-daly@uiowa.edu).
Yinghui XuFrom the University of Iowa Carver College of Medicine, Iowa City, IA (JMD, YX, RMH, BTL); University of North Carolina School of Medicine, Chapel Hill, NC (SDC); Oregon Health & Science University and Portland VA Medical Center, Portland, OR (SDC); Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA (RMH, BTL); and University of Iowa College of Public Health, Iowa City, IA (BTL).
Seth D CrockettFrom the University of Iowa Carver College of Medicine, Iowa City, IA (JMD, YX, RMH, BTL); University of North Carolina School of Medicine, Chapel Hill, NC (SDC); Oregon Health & Science University and Portland VA Medical Center, Portland, OR (SDC); Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA (RMH, BTL); and University of Iowa College of Public Health, Iowa City, IA (BTL).
Richard M HoffmanFrom the University of Iowa Carver College of Medicine, Iowa City, IA (JMD, YX, RMH, BTL); University of North Carolina School of Medicine, Chapel Hill, NC (SDC); Oregon Health & Science University and Portland VA Medical Center, Portland, OR (SDC); Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA (RMH, BTL); and University of Iowa College of Public Health, Iowa City, IA (BTL).
Barcey T LevyFrom the University of Iowa Carver College of Medicine, Iowa City, IA (JMD, YX, RMH, BTL); University of North Carolina School of Medicine, Chapel Hill, NC (SDC); Oregon Health & Science University and Portland VA Medical Center, Portland, OR (SDC); Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA (RMH, BTL); and University of Iowa College of Public Health, Iowa City, IA (BTL).

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Comparative Effectiveness of Fecal Immunochemical Tests with Optical ColonoscopyR01CA215034 · NCI · UNIVERSITY OF IOWA · PI LEVY, BARCEY THURSTON · 2017 to 2021
$4.5M
NCATS NIH HHS UL1 TR002537NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA215034
6 · The paper itself

Abstract

purposeInadequate bowel preparation (IBP) for colonoscopies is associated with missed polyps and cancers, prolonged procedure times, lower colonoscopy completion rates, and need for a repeat procedure. The purposes of this study were to assess: 1) whether impaired cognitive status (measured by an abnormal clock drawing test) was associated with IBP, and 2) the association of participant demographic and clinical characteristics with IBP.

methodsCross-sectional cohort study conducted in 3 academic centers. Subjects, 50 to 85 years old, completed 5 stool tests on a single sample and a clock drawing before undergoing a screening or surveillance colonoscopy. Clock drawings were validated by the Mendes-Santos method and Watson method. A generalized linear mixed model was conducted to estimate factors associated with IBP, based on Aronchick bowel preparation score.

resultsThe 2,016 participants had a mean age of 63 years (SD = 7.95); 1,274 (63%) were female; 119 (6%) had IBP; and 421 (21%) had an abnormal clock drawing. After controlling for age in the multivariable model, the odds of having an IBP versus adequate were 1.44 (95% CI, 0.94-2.22) for those with an abnormal clock drawing score compared with those with a normal score. The only variable significantly associated with IBP was household income, with an odds of 2.48 (95% CI, 1.56-3.95) for household income of <$40,000 compared with income >$80,000.

conclusionsLower household income was associated with greater odds of IBP. The association between an abnormal clock drawing score and IBP was not statistically significant.NCT03264898 (clinicaltrials.gov) - Comparative Effectiveness of FITs with Colonoscopy.

Indexed as

CatharticsCognitive DysfunctionColonoscopyAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedCatharticsCancer ScreeningCatharticsClock TestCognitionCognitive ImpairmentsCohort StudiesColon CancerColonoscopyCross-Sectional StudiesQuantitative ResearchScreening

Identifiers

PMID40789626
PMCPMC12616813

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.