Evidence map›Paper›PMID 40789456›Full record

ReviewThe Journal of allergy and clinical immunology2025

Mastering genetics for your clinic: A step-by-step guide.

Erica Schindewolf, Gonench Kilich, Dawn Westerfer, Dana Vandergrift, Ramakrishnan Rajagopalan, Kathleen E Sullivan

Abstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erica SchindewolfUndiagnosed Disease Program, Children's Hospital of Philadelphia, Philadelphia, Pa.
Gonench KilichUndiagnosed Disease Program, Children's Hospital of Philadelphia, Philadelphia, Pa.
Dawn WesterferUndiagnosed Disease Program, Children's Hospital of Philadelphia, Philadelphia, Pa.
Dana VandergriftUndiagnosed Disease Program, Children's Hospital of Philadelphia, Philadelphia, Pa.
Ramakrishnan RajagopalanUndiagnosed Disease Program, Children's Hospital of Philadelphia, Philadelphia, Pa.
Kathleen E SullivanUndiagnosed Disease Program, Children's Hospital of Philadelphia, Philadelphia, Pa. Electronic address: sullivank@chop.edu.

Funding

Undiagnosed diseases network clinical siteU01HG010219 · NHGRI · CHILDREN'S HOSP OF PHILADELPHIA · PI RADER, DANIEL JAMES, SULLIVAN, KATHLEEN E · 2018 to 2022
$3.0M
Utilizing long-read sequencing to resolve inconclusive diagnoses and uncertainty in genetic testingR01HG013355 · NHGRI · CHILDREN'S HOSP OF PHILADELPHIA · PI Ramakrishnan Rajagopalan · 2024 to 2026
$1.3M
UDN@CHOP/UPENN: transition to sustainabilityU01NS134352 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI RADER, DANIEL JAMES, SULLIVAN, KATHLEEN E · 2023 to 2023
$975k
NHGRI NIH HHS R01 HG013355NHGRI NIH HHS U01 HG010219NINDS NIH HHS U01 NS134352
6 · The paper itself

Abstract

The use of genetics has transformed nearly every medical specialty. Allergy and immunology are no exceptions, and finding a way to harness data of this type requires mastery of some new skills to serve our patients. This review covers who should be tested, what testing is appropriate, how to interpret of results, and how to apply the results for patient management. Additional case studies with step-by-step workflows and other resources are provided in the Supplemental Methods (available in the Online Repository at www.jacionline.org).

Indexed as

Allergy and ImmunologyGenetic TestingHypersensitivityHumansgeneticsmutationOmicsvariant interpretationVUSWESWGS

Identifiers

PMID40789456
PMCPMC13157676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.